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dc.contributor.author | Weinberger, Tobias | |
dc.contributor.author | Denise, Messerer | |
dc.contributor.author | Joppich, Markus | |
dc.contributor.author | Fischer, Maximilian | |
dc.contributor.author | Garcia Rodriguez, Clarisabel | |
dc.contributor.author | Kumaraswami, Konda | |
dc.contributor.author | Wimmler, Vanessa | |
dc.contributor.author | Ablinger, Sonja | |
dc.contributor.author | Räuber, Saskia | |
dc.contributor.author | Fang, Jiahui | |
dc.contributor.author | Liu, Lulu | |
dc.contributor.author | Liu, Wing Han | |
dc.contributor.author | Winterhalter, Julia | |
dc.contributor.author | Lichti, Johannes | |
dc.contributor.author | Thomas, Lukas | |
dc.contributor.author | Esfandyari, Dena | |
dc.contributor.author | Percin, Guelce | |
dc.contributor.author | Matin, Sandra | |
dc.contributor.author | Hidalgo, Andres | |
dc.contributor.author | Waskow, Claudia | |
dc.contributor.author | Engelhardt, Stefan | |
dc.contributor.author | Todica, Andrei | |
dc.contributor.author | Zimmer, Ralf | |
dc.contributor.author | Pridans, Clare | |
dc.contributor.author | Gomez Perdiguero, Elisa | |
dc.contributor.author | Schulz, Christian | |
dc.date.accessioned | 2024-07-03T12:52:32Z | |
dc.date.available | 2024-07-03T12:52:32Z | |
dc.date.issued | 2024-05-22 | |
dc.identifier.citation | Elife. 2024 May 22:12:RP89377. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20030 | |
dc.description.abstract | Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion (I/R) injury remains incomplete. We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner. Genomic deletion of a fms-intronic regulatory element (FIRE) in the Csf1r locus resulted in specific absence of resident homeostatic and antigen-presenting macrophages, without affecting the recruitment of monocyte-derived macrophages to the infarcted heart. Specific absence of homeostatic, monocyte-independent macrophages altered the immune cell crosstalk in response to injury and induced proinflammatory neutrophil polarization, resulting in impaired cardiac remodeling without influencing infarct size. In contrast, continuous CSF1R inhibition led to depletion of both resident and recruited macrophage populations. This augmented adverse remodeling after I/R and led to an increased infarct size and deterioration of cardiac function. In summary, resident macrophages orchestrate inflammatory responses improving cardiac remodeling, while recruited macrophages determine infarct size after I/R injury. These findings attribute distinct beneficial effects to different macrophage populations in the context of myocardial infarction. | es_ES |
dc.description.sponsorship | DZHK (German Centre for Cardiovascular Research) and the BMBF (German Ministry of Education and Research) (grants 81Z0600204 to CS, 81×2600252 to TW and 81×2600256 to MF). The Deutsche Forschungsgemeinschaft (SCHU 2297/1-1 and collaborative research centers 1123 project Z02 (MJ, RZ) and A07 (CS), and CRC TRR332 project A6 (CS). LMUexcellent (TW). ESC Research Grant 2021 (TW). Friedrich-Baur Stiftung (TW). Deutsche Stiftung für Herzforschung (M.F.). Chinese Scholarship Council (CSC) to JF and LL. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | eLife Sciences Publications | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Macrophages | es_ES |
dc.subject.mesh | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Myocardial Ischemia | es_ES |
dc.subject.mesh | Myocardial Infarction | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Myocardial Reperfusion Injury | es_ES |
dc.subject.mesh | Mice, Inbred C57BL | es_ES |
dc.subject.mesh | Myocardium | es_ES |
dc.subject.mesh | Disease Models, Animal | es_ES |
dc.title | Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 38775664 | es_ES |
dc.format.volume | 12 | es_ES |
dc.identifier.doi | 10.7554/eLife.89377 | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2050-084X | es_ES |
dc.relation.publisherversion | 10.7554/eLife.89377 | es_ES |
dc.identifier.journal | eLife | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |