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dc.contributor.author | Restrepo-Córdoba, María Alejandra | |
dc.contributor.author | Chmielewski, Przemyslaw | |
dc.contributor.author | Truszkowska, Grażyna | |
dc.contributor.author | Peña-Peña, María Luisa | |
dc.contributor.author | Kubánek, Miloš | |
dc.contributor.author | Krebsová, Alice | |
dc.contributor.author | Lopes, Luis R | |
dc.contributor.author | García-Ropero, Álvaro | |
dc.contributor.author | Merlo, Marco | |
dc.contributor.author | Paldino, Alessia | |
dc.contributor.author | Peters, Stacey | |
dc.contributor.author | Jurcut, Ruxandra | |
dc.contributor.author | Barriales-Villa, Roberto | |
dc.contributor.author | Zorio, Esther | |
dc.contributor.author | Hazebroek, Mark | |
dc.contributor.author | Mogensen, Jens | |
dc.contributor.author | Garcia-Pavia, Pablo | |
dc.date.accessioned | 2024-07-03T09:11:02Z | |
dc.date.available | 2024-07-03T09:11:02Z | |
dc.date.issued | 2024-04-18 | |
dc.identifier.citation | Rev Esp Cardiol. 2024 Apr 18:S1885-5857(24)00128-2. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19928 | |
dc.description.abstract | INTRODUCTION AND OBJECTIVES Limited information is available on the safety of pregnancy in patients with genetic dilated cardiomyopathy (DCM) and in carriers of DCM-causing genetic variants without the DCM phenotype. We assessed cardiac, obstetric, and fetal or neonatal outcomes in this group of patients. METHODS We studied 48 women carrying pathogenic or likely pathogenic DCM-associated variants (30 with DCM and 18 without DCM) who had 83 pregnancies. Adverse cardiac events were defined as heart failure (HF), sustained ventricular tachycardia, ventricular assist device implantation, heart transplant, and/or maternal cardiac death during pregnancy, or labor and delivery, and up to the sixth postpartum month. RESULTS A total of 15 patients, all with DCM (31% of the total cohort and 50% of women with DCM) experienced adverse cardiac events. Obstetric and fetal or neonatal complications were observed in 14% of pregnancies (10 in DCM patients and 2 in genetic carriers). We analyzed the 30 women who had been evaluated before their first pregnancy (12 with overt DCM and 18 without the phenotype). Five of the 12 (42%) women with DCM had adverse cardiac events despite showing NYHA class I or II before pregnancy. Most of these women had a history of cardiac events before pregnancy (80%). Among the 18 women without phenotype, 3 (17%) developed DCM toward the end of pregnancy. CONCLUSIONS Cardiac complications during pregnancy and postpartum were common in patients with genetic DCM and were primarily related to HF. Despite apparently good tolerance of pregnancy in unaffected genetic carriers, pregnancy may act as a trigger for DCM onset in a subset of these women. | es_ES |
dc.description.sponsorship | P. Chmielewski and G. Truszkowska were supported by DETECTIN-HF grant from ERA-CVD framework, NCBiR. M. Kuba´nek was supported by the research grant MH CZ [NV19-08-00122], MH CZ-DRO (IKEM, IN 00023001) and by the National Institute for Research of Metabolic and Cardiovascular Diseases project (EXCELES Programme, Project No. LX22NPO5104), Funded by the European Union-Next Generation EU. L.R. Lopes was supported by an MRC UK Clinical Academic Partnership Award (CARP) MR/ T005181/1. MA Restrepo-Co´ rdoba was supported by a grant from SEC-ROVI for the Promotion of Research in Heart Failure from the Heart Failure Section, Spanish Society of Cardiology. P. Garcı´aPavı´a and M. Hazebroek are funded by the Pathfinder Cardiogenomics programme of the European Innovation Council of the European Union (DCM-NEXT project; project number: 101115416). The CNIC is supported by the ISCIII, MCIN, the ProCNIC Foundation, and the Severo Ochoa Centers of Excellence program (CEX2020-001041-S). The Hospital Universitario Puerta de Hierro, the Hospital Universitario Virgen del Rocı´o, the Azienda Sanitaria Universitaria Giuliano-Isontina, the Institute for Clinical and Experimental Medicine, the Maastricht University Medical Center and the Expert Center for Rare Genetic Cardiovascular Diseases, Emergency Institute for Cardiovascular Diseases are members of the European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart (ERN GUARDHeart). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Ediciones Doyma | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Pregnancy in women with dilated cardiomyopathy genetic variants. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 38641168 | es_ES |
dc.identifier.doi | 10.1016/j.rec.2024.04.002 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. NextGenerationEU | es_ES |
dc.contributor.funder | Sociedad Española de Cardiología | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1885-5857 | es_ES |
dc.relation.publisherversion | 10.1016/j.rec.2024.04.002 | es_ES |
dc.identifier.journal | Revista espanola de cardiologia (English ed.) | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Miocardiopatías Hereditarias | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |