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dc.contributor.author | Makhlin, Igor | |
dc.contributor.author | Demissei, Biniyam G | |
dc.contributor.author | D'Agostino, Ralph | |
dc.contributor.author | Hundley, W Greg | |
dc.contributor.author | Baleanu-Gogonea, Camelia | |
dc.contributor.author | Wilcox, Nicholas S | |
dc.contributor.author | Chen, Anna | |
dc.contributor.author | Smith, Amanda M | |
dc.contributor.author | O'Connell, Nathaniel Sean | |
dc.contributor.author | Januzzi, James L | |
dc.contributor.author | Lesser, Glenn J | |
dc.contributor.author | Scherrer-Crosbie, Marielle | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Tang, W H Wilson | |
dc.contributor.author | Ky, Bonnie | |
dc.date.accessioned | 2024-07-03T08:46:21Z | |
dc.date.available | 2024-07-03T08:46:21Z | |
dc.date.issued | 2024-06-03 | |
dc.identifier.citation | Clin Cancer Res. 2024 Jun 3;30(11):2370-2376. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19926 | |
dc.description.abstract | PURPOSE Preventing Anthracycline Cardiovascular Toxicity with Statins (PREVENT; NCT01988571) randomized patients with breast cancer or lymphoma receiving anthracyclines to atorvastatin 40 mg daily or placebo. We evaluated the effects of atorvastatin on oxidative and nitrosative stress biomarkers, and explored whether these biomarkers could explain the lack of effect of atorvastatin on LVEF (left ventricular ejection fraction) in PREVENT. PATIENTS AND METHODS Blood samples were collected and cardiac MRI was performed before doxorubicin initiation and at 6 and 24 months. Thirteen biomarkers [arginine-nitric oxide metabolites, paraoxonase-1 (PON-1) activity, and myeloperoxidase] were measured. Dimensionality reduction using principal component analysis was used to define biomarker clusters. Linear mixed-effects models determined the changes in biomarkers over time according to treatment group. Mediation analysis determined whether biomarker clusters explained the lack of effect of atorvastatin on LVEF. RESULTS Among 202 participants with available biomarkers, median age was 53 years; 86.6% had breast cancer; median LVEF was 62%. Cluster 1 levels, reflecting arginine methylation metabolites, were lower over time with atorvastatin, although this was not statistically significant (P = 0.081); Cluster 2 levels, reflecting PON-1 activity, were significantly lower with atorvastatin (P = 0.024). There were no significant changes in other biomarker clusters (P > 0.05). Biomarker clusters did not mediate an effect of atorvastatin on LVEF (P > 0.05). CONCLUSIONS Atorvastatin demonstrated very modest effects on oxidative/nitrosative stress biomarkers in this low cardiovascular risk population. Our findings provide potential mechanistic insight into the lack of effect of atorvastatin on LVEF in the PREVENT trial. | es_ES |
dc.description.sponsorship | Research funding for this study was provided by the National Institutes of Health (Grants NIH R01HL118740 (WGH), R21HL14802 (BK), R01HL118018 (BK), UG1CA189824 (GL Research Base), UG1CA189828 (BK, ECOG ACRIN Research Base), U10CA081851 (Wake Forest Research Base), and UG1CA189823 (Alliance NCORP Research Base)). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association for Cancer Research (AACR) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Oxidative Stress | es_ES |
dc.subject.mesh | Hydroxymethylglutaryl-CoA Reductase Inhibitors | es_ES |
dc.subject.mesh | Biomarkers | es_ES |
dc.subject.mesh | Nitrosative Stress | es_ES |
dc.subject.mesh | Atorvastatin | es_ES |
dc.subject.mesh | Breast Neoplasms | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Doxorubicin | es_ES |
dc.subject.mesh | Aryldialkylphosphatase | es_ES |
dc.subject.mesh | Arginine | es_ES |
dc.title | Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 38573708 | es_ES |
dc.format.volume | 30 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | 2370 | es_ES |
dc.identifier.doi | 10.1158/1078-0432.CCR-23-3952 | es_ES |
dc.contributor.funder | National Institutes of Health (Estados Unidos) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1557-3265 | es_ES |
dc.relation.publisherversion | 10.1158/1078-0432.CCR-23-3952 | es_ES |
dc.identifier.journal | Clinical cancer research : an official journal of the American Association for Cancer Research | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |