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dc.contributor.author | Palomo, Iván | |
dc.contributor.author | Wehinger, Sergio | |
dc.contributor.author | Andres, Vicente | |
dc.contributor.author | García-García, Francisco J | |
dc.contributor.author | Fuentes, Eduardo | |
dc.date.accessioned | 2024-07-02T14:46:44Z | |
dc.date.available | 2024-07-02T14:46:44Z | |
dc.date.issued | 2024-04 | |
dc.identifier.citation | J Cell Mol Med. 2024 Apr;28(8):e18153. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19918 | |
dc.description.abstract | The small GTPase RhoA and the downstream Rho kinase (ROCK) regulate several cell functions and pathological processes in the vascular system that contribute to the age-dependent risk of cardiovascular disease, including endothelial dysfunction, excessive permeability, inflammation, impaired angiogenesis, abnormal vasoconstriction, decreased nitric oxide production and apoptosis. Frailty is a loss of physiological reserve and adaptive capacity with advanced age and is accompanied by a pro-inflammatory and pro-oxidative state that promotes vascular dysfunction and thrombosis. This review summarises the role of the RhoA/Rho kinase signalling pathway in endothelial dysfunction, the acquisition of the pro-thrombotic state and vascular ageing. We also discuss the possible role of RhoA/Rho kinase signalling as a promising therapeutic target for the prevention and treatment of age-related cardiovascular disease. | es_ES |
dc.description.sponsorship | This research was funded by ANID/FONDECYT grant no. 1220339, ANID/ FONDECYT grant no. 1211136 and ANID-FONDEQUIP No. EQM200049 (Flow Cytometry). We would also like to thank ANID-Ring ACT210097 (MIBI: Interdisciplinary Group on Mitochondrial Targeting and Bioenergetics), ANID-FOVI210024, ANID-FOVI210022, ANID-FOVI220021, the Spanish Ministerio de Ciencia, Innovación y Universidades and Agencia Estatal de Investigación (MICIN/AEI/10.13039/501100033, grant no. PID2022-141211OB-I00), with co-funding from the European Social Fund (ESF) (The ESF-Investing in your future), and Fundación Ramón Areces (grant no. CIVP21S13281). The CNIC is supported by the Ministerio de Ciencia e Innovación, the Instituto de Salud Carlos III, the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (grant number CEX2020-001041-S funded by MCIN/AEI/10.13039/501100011033). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Cardiovascular Diseases | es_ES |
dc.subject.mesh | Thrombosis | es_ES |
dc.subject.mesh | Vascular Diseases | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | rho-Associated Kinases | es_ES |
dc.subject.mesh | Endothelial Cells | es_ES |
dc.title | RhoA/rho kinase pathway activation in age-associated endothelial cell dysfunction and thrombosis. | es_ES |
dc.type | review article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 38568071 | es_ES |
dc.format.volume | 28 | es_ES |
dc.format.number | 8 | es_ES |
dc.format.page | e18153 | es_ES |
dc.identifier.doi | 10.1111/jcmm.18153 | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1582-4934 | es_ES |
dc.relation.publisherversion | 10.1111/jcmm.18153 | es_ES |
dc.identifier.journal | Journal of cellular and molecular medicine | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genética | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/CIVP21S13281 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MICIN/AEI/10.13039/501100033 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2022-141211OB-I00 | es_ES |