dc.contributor.author | Swanton, Charles | |
dc.contributor.author | Bernard, Elsa | |
dc.contributor.author | Abbosh, Chris | |
dc.contributor.author | André, Fabrice | |
dc.contributor.author | Auwerx, Johan | |
dc.contributor.author | Balmain, Allan | |
dc.contributor.author | Bar-Sagi, Dafna | |
dc.contributor.author | Bernards, René | |
dc.contributor.author | Bullman, Susan | |
dc.contributor.author | DeGregori, James | |
dc.contributor.author | Elliott, Catherine | |
dc.contributor.author | Erez, Ayelet | |
dc.contributor.author | Evan, Gerard | |
dc.contributor.author | Febbraio, Mark A | |
dc.contributor.author | Hidalgo, Andres | |
dc.contributor.author | Jamal-Hanjani, Mariam | |
dc.contributor.author | Joyce, Johanna A | |
dc.contributor.author | Kaiser, Matthew | |
dc.contributor.author | Lamia, Katja | |
dc.contributor.author | Locasale, Jason W | |
dc.contributor.author | Loi, Sherene | |
dc.contributor.author | Malanchi, Ilaria | |
dc.contributor.author | Merad, Miriam | |
dc.contributor.author | Musgrave, Kathryn | |
dc.contributor.author | Patel, Ketan J | |
dc.contributor.author | Quezada, Sergio | |
dc.contributor.author | Wargo, Jennifer A | |
dc.contributor.author | Weeraratna, Ashani | |
dc.contributor.author | White, Eileen | |
dc.contributor.author | Winkler, Frank | |
dc.contributor.author | Wood, John N | |
dc.contributor.author | Vousden, Karen H | |
dc.contributor.author | Hanahan, Douglas | |
dc.date.accessioned | 2024-07-02T14:25:41Z | |
dc.date.available | 2024-07-02T14:25:41Z | |
dc.date.issued | 2024-03-28 | |
dc.identifier.citation | Cell. 2024 Mar 28;187(7):1589-1616. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19916 | |
dc.description.abstract | The last 50 years have witnessed extraordinary developments in understanding mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical framework, our understanding of the molecular basis of systemic manifestations and the underlying causes of cancer-related death remains incomplete. Looking forward, elucidating how tumors interact with distant organs and how multifaceted environmental and physiological parameters impinge on tumors and their hosts will be crucial for advances in preventing and more effectively treating human cancers. In this perspective, we discuss complexities of cancer as a systemic disease, including tumor initiation and promotion, tumor micro- and immune macro-environments, aging, metabolism and obesity, cancer cachexia, circadian rhythms, nervous system interactions, tumor-related thrombosis, and the microbiome. Model systems incorporating human genetic variation will be essential to decipher the mechanistic basis of these phenomena and unravel gene-environment interactions, providing a modern synthesis of molecular oncology that is primed to prevent cancers and improve patient quality of life and cancer outcomes. | es_ES |
dc.description.sponsorship | CRUK thanks Alison Howe for her generosity in supporting the creation of the
CRUK Marshall Symposium series and Lucy Stuart for coordinating the organization of this workshop. J.A. was supported by Ecole Polytechnique Fe´ de´rale de Lausanne (EPFL), and grants from the European Research Council
(ERC-AdG-787702) and the Swiss National Science Foundation (SNSF
31003A_179435). A.B. is supported by National Cancer Institutes (NCI) grant
R35CA210018; Barbara Bass Bakar Professorship of Cancer Genetics; Cancer Research UK/NCI PROMINENT Cancer Grand Challenge Award (Project
Number: OT2CA278665 and CGCATF-2021/100006), D.B.-S. NIH/National
Cancer Institute (NCI) grant R35CA210263. R.B. was supported by ERC787925. J.D. was supported by R01AG067584. A.E. was supported by
ERC818943, ISF860/18, and ICRF 837124. M.A.F. was supported by an Investigator Grant APP1194141 from the National Health & Medical Research Council of Australia (NHMRC). A.H. was supported by 1R01AI165661. J.A.J. was
supported by the Swiss National Science Foundation Advanced Grant
TMAG-3_209224, Ludwig Institute for Cancer Research, and the University
of Lausanne. K.L. was supported by CA271500. I.M. was supported by ERC
CoGH2020-725492; Francis Crick Institute/Wellcome Trust CC2051; Francis
Crick Institute/UK Medical Research Council CC2051; Francis Crick
Institute/Cancer Research UK CC2051. K.H.V. was supported by Cancer
Research UK grant C596/A26855; Francis Crick Institute/Wellcome Trust
CC2073; Francis Crick Institute/UK Medical Research Council CC2073; Francis Crick Institute/Cancer Research UK. E.W. was supported by the CRUK/
NCI Cancer Grand Challenge CANCAN award, the Ludwig Institute for Cancer
Research, NCI grants CA163591 and CA243547, and the Fifth Generation
Foundation. F.W. was supported by the Deutsche Forschungsgemeinschaft
(SFB 1389, UNITE Glioblastoma). D.H. was supported by the Ludwig Institute
for Cancer Research. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Neoplasms | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Carcinogenesis | es_ES |
dc.subject.mesh | Microbiota | es_ES |
dc.subject.mesh | Obesity | es_ES |
dc.subject.mesh | Quality of Life | es_ES |
dc.title | Embracing cancer complexity: Hallmarks of systemic disease. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 38552609 | es_ES |
dc.format.volume | 187 | es_ES |
dc.format.number | 7 | es_ES |
dc.format.page | 1589 | es_ES |
dc.identifier.doi | 10.1016/j.cell.2024.02.009 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Swiss National Science Foundation | es_ES |
dc.contributor.funder | NIH - National Cancer Institute (NCI) (Estados Unidos) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1097-4172 | es_ES |
dc.relation.publisherversion | 10.1016/j.cell.2024.02.009 | es_ES |
dc.identifier.journal | Cell | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC-AdG-787702 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/787925 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/818943 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/CoGH2020-725492 | es_ES |
dc.rights.accessRights | open access | es_ES |