dc.contributor.author | Muñoz-Hernando, María | |
dc.contributor.author | Nogales, Paula | |
dc.contributor.author | Fernández-Barahona, Irene | |
dc.contributor.author | Ruiz-Cabello, Jesús | |
dc.contributor.author | Bentzon, Jacob F | |
dc.contributor.author | Herranz, Fernando | |
dc.date.accessioned | 2024-05-17T15:09:35Z | |
dc.date.available | 2024-05-17T15:09:35Z | |
dc.date.issued | 2024-03-28 | |
dc.identifier.citation | Nanoscale. 2024 Mar 28;16(13):6477-6487. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19445 | |
dc.description.abstract | Atherosclerosis, a leading cause of cardiovascular diseases requires approaches to enhance disease monitoring and treatment. Nanoparticles offer promising potential in this area by being customisable to target components or molecular processes within plaques, while carrying diagnostic and therapeutic agents. However, the number of biomarkers available to target this disease is limited. This study investigated the use of sphingomyelin-based nanomicelles triggered by sphingomyelinase (SMase) in atherosclerotic plaques. Accumulation of iron oxide-based nanomicelles in the plaque was demonstrated by fluorescence, MR imaging and electron microscopy. These findings demonstrate the possibility of utilising SMase as a mechanism to retain nanoprobes within plaques, thus opening up possibilities for future therapeutic interventions. | es_ES |
dc.description.sponsorship | This study was supported by grants from the Ministerio de
Economía, Industria y Competitividad (MEIC) with cofunding
from the European Regional Development Fund (PID2019-
108568RB-I00) and Ministerio de Ciencia e Innovación
(PID2019-104059RB-100, PDC2022-133493-100, RED2022-
134299-T), Comunidad de Madrid (P2022/BMD-7333) and La
Caixa Health Research Programme (HR20-00075,
AtheroConvergence). CNIC is supported by the Instituto de
Salud Carlos III (ISCIII), the Ministerio de Ciencia e
Innovación (MCIN) and the Pro CNIC Foundation, and is a
Severo Ochoa Center of Excellence (grant CEX2020-001041-S
funded by MICIN/AEI/10.13039/501100011033). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry (RSC) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Plaque, Atherosclerotic | es_ES |
dc.subject.mesh | Nanoparticles | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Sphingomyelin Phosphodiesterase | es_ES |
dc.subject.mesh | Magnetic Resonance Imaging | es_ES |
dc.title | Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis. | es_ES |
dc.type | journal article | es_ES |
dc.identifier.pubmedID | 38426659 | es_ES |
dc.format.volume | 16 | es_ES |
dc.format.number | 13 | es_ES |
dc.format.page | 6477 | es_ES |
dc.identifier.doi | 10.1039/d3nr06507c | es_ES |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Comunidad de Madrid (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2040-3372 | es_ES |
dc.relation.publisherversion | 10.1039/d3nr06507c | es_ES |
dc.identifier.journal | Nanoscale | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Patología Experimental de la Aterosclerosis | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2019-108568RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2019-104059RB-100 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PDC2022-133493-100 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RED2022-134299-T | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/P2022/BMD-7333 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR20-00075 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MICIN/AEI/10.13039/501100011033/CEX2020-001041-S | es_ES |