Mostrar el registro sencillo del ítem
dc.contributor.author | Aroca-Crevillén, Alejandra | |
dc.contributor.author | Vicanolo, Tommaso | |
dc.contributor.author | Ovadia, Samuel | |
dc.contributor.author | Hidalgo, Andres | |
dc.date.accessioned | 2024-05-10T12:31:45Z | |
dc.date.available | 2024-05-10T12:31:45Z | |
dc.date.issued | 2024-01-24 | |
dc.identifier.citation | Annu Rev Pathol. 2024 Jan 24:19:227-259. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19363 | |
dc.description.abstract | Infections, cardiovascular disease, and cancer are major causes of disease and death worldwide. Neutrophils are inescapably associated with each of these health concerns, by either protecting from, instigating, or aggravating their impact on the host. However, each of these disorders has a very different etiology, and understanding how neutrophils contribute to each of them requires understanding the intricacies of this immune cell type, including their immune and nonimmune contributions to physiology and pathology. Here, we review some of these intricacies, from basic concepts in neutrophil biology, such as their production and acquisition of functional diversity, to the variety of mechanisms by which they contribute to preventing or aggravating infections, cardiovascular events, and cancer. We also review poorly explored aspects of how neutrophils promote health by favoring tissue repair and discuss how discoveries about their basic biology inform the development of new therapeutic strategies. | es_ES |
dc.description.sponsorship | We thank all members of our laboratory and colleagues worldwide for discussion and contributions to the concepts summarized in this review. Work in our lab is supported by grants R01AI165661 from the National Institutes of Health and National Institute of Allergy and Infectious Disease, RTI2018-095497-B-I00 from the Ministerio de Ciencia e Innovacion (MCIN), HR17_00527 from Fundación La Caixa, and FET-OPEN 861878 from the European Commission. A.A-C. and T.V. are supported by fellowships from la Caixa Foundation (ID 100010434), with codes LCF/BQ/DR19/11740022 (A.A-C.) and LCF/BQ/DR21/11880022 (T.V.). The CNIC is supported by the MCIN and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (CEX2020-001041-S). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ANNUAL REVIEWS | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Cardiovascular Diseases | es_ES |
dc.subject.mesh | Neoplasms | es_ES |
dc.subject.mesh | Cardiovascular Infections | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Neutrophils | es_ES |
dc.subject.mesh | Health Promotion | es_ES |
dc.title | Neutrophils in Physiology and Pathology. | es_ES |
dc.type | review article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 38265879 | es_ES |
dc.format.volume | 19 | es_ES |
dc.format.page | 227 | es_ES |
dc.identifier.doi | 10.1146/annurev-pathmechdis-051222-015009 | es_ES |
dc.contributor.funder | National Institutes of Health (Estados Unidos) | es_ES |
dc.contributor.funder | NIH - National Institute of Allergy and Infectious Diseases (NIAID) (Estados Unidos) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1553-4014 | es_ES |
dc.relation.publisherversion | 10.1146/annurev-pathmechdis-051222-015009 | es_ES |
dc.identifier.journal | Annual review of pathology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/FET-OPEN/861878 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-095497-B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR17_00527 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/100010434 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/BQ/DR19/11740022 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/BQ/DR21/11880022 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |