dc.contributor.author | Fernández-Pena, Alberto | |
dc.contributor.author | Navas-Sánchez, Francisco J | |
dc.contributor.author | de Blas, Daniel Martín | |
dc.contributor.author | Marcos-Vidal, Luis | |
dc.contributor.author | Desco, Manuel | |
dc.contributor.author | Carmona, Susanna | |
dc.date.accessioned | 2024-05-10T10:11:43Z | |
dc.date.available | 2024-05-10T10:11:43Z | |
dc.date.issued | 2024-01 | |
dc.identifier.citation | Hum Brain Mapp. 2024 Jan;45(1):e26538. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19357 | |
dc.description.abstract | Surgical menopause causes a sharp drop in estrogen levels in middle-aged women, thus preventing the gradual physiological adaptation that is characteristic of the perimenopause. Previous studies suggest that surgical menopause might increase the risk of dementia later in life. In addition, the transition to motherhood entails long-lasting endocrine and neuronal adaptations. We compared differences in whole-brain cortical volume between women who reached menopause by surgery and a group of women who reached spontaneous non-surgical menopause and determined whether these cortical differences were influenced by previous childbearing. Using surface-based neuroimaging techniques, we investigated cortical volume differences in 201 middle-aged women (134 women who experienced non-surgical menopause, 78 of whom were parous women; and 67 women who experienced surgical menopause, 39 of whom were parous women). We found significant atrophy in the frontal and temporal regions in women who experienced surgical menopause. Nulliparous women with surgical menopause showed significant lower cortical volume in the left temporal gyrus extending to the medial temporal lobe cortex, as well as in the precuneus bilaterally compared to parous women with surgical menopause; whereas our results revealed no significant differences between parous women with surgical menopause and both parous and nulliparous women who reached a non-surgical menopause. Furthermore, in the surgical menopause group, we found a negative correlation between cortical volume and age at first pregnancy in the temporal lobe. Our study suggests that the long-term brain remodeling of parity may mitigate the neural impact of the sudden drop in estrogen levels that characterizes surgical menopause. | es_ES |
dc.description.sponsorship | This study has been funded by Instituto de Salud Carlos III through
the project PI22/01365, co-funded by European Regional Development Fund “A way to make Europe”. Susanna Carmona funded by
Instituto de Salud Carlos III, co-funded by European Social Fund
“Investing in your future (grant CPII21/00016)”. The project leading
to these results has received funding from “la Caixa” Foundation
under the project code LCF/PR/HR19/52160001, from the European
Research Council (ERC) under the “European Union's Horizon 2020”
research and innovation programme (grant agreement no. 883069),
and from the Centro Nacional de Investigaciones Cardiovasculares
(CNIC). The CNIC is supported by the Ministerio de Ciencia,
Innovacion y Universidades and the Pro CNIC Foundation, and is a
Severo Ochoa Center of Excellence (SEV-2015-050). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Perimenopause | es_ES |
dc.subject.mesh | Menopause | es_ES |
dc.subject.mesh | Pregnancy | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Parity | es_ES |
dc.subject.mesh | Brain | es_ES |
dc.subject.mesh | Estrogens | es_ES |
dc.title | Previous pregnancies might mitigate cortical brain differences associated with surgical menopause. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 38063284 | es_ES |
dc.format.volume | 45 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | e26538 | es_ES |
dc.identifier.doi | 10.1002/hbm.26538 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. H2020 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1097-0193 | es_ES |
dc.relation.publisherversion | 10.1002/hbm.26538 | es_ES |
dc.identifier.journal | Human brain mapping | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Imagen Avanzada | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/CPII21/00016 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/883069 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/PR/HR19/52160001 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SEV-2015-050 | es_ES |