dc.contributor.author | Li, Wenlu | |
dc.contributor.author | Mandeville, Emiri T | |
dc.contributor.author | Durán-Laforet, Violeta | |
dc.contributor.author | Fukuda, Norito | |
dc.contributor.author | Yu, Zhanyang | |
dc.contributor.author | Zheng, Yi | |
dc.contributor.author | Held, Aaron | |
dc.contributor.author | Park, Ji-Hyun | |
dc.contributor.author | Nakano, Takafumi | |
dc.contributor.author | Tanaka, Masayoshi | |
dc.contributor.author | Shi, Jingfei | |
dc.contributor.author | Esposito, Elga | |
dc.contributor.author | Niu, Wanting | |
dc.contributor.author | Xing, Changhong | |
dc.contributor.author | Hayakawa, Kazuhide | |
dc.contributor.author | Lizasoain, Ignacio | |
dc.contributor.author | van Leyen, Klaus | |
dc.contributor.author | Ji, Xunming | |
dc.contributor.author | Wainger, Brian J | |
dc.contributor.author | Moro, Maria A | |
dc.contributor.author | Lo, Eng H | |
dc.date.accessioned | 2024-05-09T12:02:54Z | |
dc.date.available | 2024-05-09T12:02:54Z | |
dc.date.issued | 2022-12-19 | |
dc.identifier.citation | Nat Commun. 2022 Dec 19;13(1):7812. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19324 | |
dc.description.abstract | The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon where brain endothelial cells may release trans-differentiation signals that convert astrocytes into neural progenitor cells in male mice after stroke. After oxygen-glucose deprivation, brain endothelial cells release microvesicles containing pro-neural factor Ascl1 that enter into astrocytes to induce their trans-differentiation into neural progenitors. In mouse models of focal cerebral ischemia, Ascl1 is upregulated in endothelium prior to astrocytic conversion into neural progenitor cells. Injecting brain endothelial-derived microvesicles amplifies the process of astrocyte trans-differentiation. Endothelial-specific overexpression of Ascl1 increases the local conversion of astrocytes into neural progenitors and improves behavioral recovery. Our findings describe an unexpected vascular-regulated mechanism of neuroplasticity that may open up therapeutic opportunities for improving outcomes after stroke. | es_ES |
dc.description.sponsorship | Supported in part by the Leducq Foundation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Stroke | es_ES |
dc.subject.mesh | Neural Stem Cells | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Astrocytes | es_ES |
dc.subject.mesh | Endothelial Cells | es_ES |
dc.subject.mesh | Cells, Cultured | es_ES |
dc.subject.mesh | Cell Transdifferentiation | es_ES |
dc.title | Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 36535938 | es_ES |
dc.format.volume | 13 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 7812 | es_ES |
dc.identifier.doi | 10.1038/s41467-022-35498-6 | es_ES |
dc.contributor.funder | Fondation Leducq | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2041-1723 | es_ES |
dc.relation.publisherversion | 10.1038/s41467-022-35498-6 | es_ES |
dc.identifier.journal | Nature communications | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Neurovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |