dc.contributor.author | Pereda, Daniel | |
dc.contributor.author | García-Lunar, Inés | |
dc.contributor.author | Sierra, Federico | |
dc.contributor.author | Sánchez-Quintana, Damián | |
dc.contributor.author | Santiago, Evelyn | |
dc.contributor.author | Ballesteros, Constanza | |
dc.contributor.author | Encalada, Juan F | |
dc.contributor.author | Sánchez-González, Javier | |
dc.contributor.author | Fuster, Valentín | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | García-Álvarez, Ana | |
dc.date.accessioned | 2024-03-14T12:56:56Z | |
dc.date.available | 2024-03-14T12:56:56Z | |
dc.date.issued | 2016-09 | |
dc.identifier.citation | Circ Cardiovasc Imaging. 2016 Sep;9(9):e004566. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/18938 | |
dc.description.abstract | BACKGROUND
Pulmonary hypertension (PH) and right ventricular (RV) dysfunction are strong predictors of morbidity and mortality among patients with congenital heart disease. Early detection of RV involvement may be useful in the management of these patients. We aimed to assess progressive cardiac adaptation and quantify myocardial extracellular volume in an experimental porcine model of PH because of aorto-pulmonary shunt using cardiac magnetic resonance (CMR).
METHODS AND RESULTS
To characterize serial cardiac adaptation, 12 pigs (aorto-pulmonary shunt [n=6] or sham operation [n=6]) were evaluated monthly with right heart catheterization, CMR, and computed tomography during 4 months, followed by pathology analysis. Extracellular volume by CMR in different myocardial regions was studied in 20 animals (aorto-pulmonary shunt [n=10] or sham operation [n=10]) 3 months after the intervention. All shunted animals developed PH. CMR evidenced progressive RV hypertrophy and dysfunction secondary to increased afterload and left ventricular dilatation secondary to volume overload. Shunt flow by CMR strongly correlated with PH severity, left ventricular end-diastolic pressure, and left ventricular dilatation. T1-mapping sequences demonstrated increased extracellular volume at the RV insertion points, the interventricular septum, and the left ventricular lateral wall, reproducing the pattern of fibrosis found on pathology. Extracellular volume at the RV insertion points strongly correlated with pulmonary hemodynamics and RV dysfunction.
CONCLUSIONS
Prolonged systemic-to-pulmonary shunting in growing piglets induces PH with biventricular remodeling and myocardial fibrosis that can be detected and monitored using CMR. These results may be useful for the diagnosis and management of congenital heart disease patients with pulmonary overcirculation. | es_ES |
dc.description.sponsorship | This work was supported by a competitive grant from the Spanish
Ministry of Economy and Competitiveness (MINECO) through
the Carlos III Institute of Health-Fondo de Investigación Sanitaria
and European Regional Development Fund (ERDF/FEDER) funds
(PI13/02339 to Dr García-Álvarez) and by the competitive grant
CNIC-Translational 01-2009 (to Dr Ibáñez). Other sponsors were
a grant TIN2012–37546-C03-02 from the Ministerio de Economía
y Competitividad (to Dr Sánchez-Quintana), a FPU program
(13/02662) from the Ministerio de Educación, Cultura y Deporte (to
F. Sierra) and a Master Research Agreement (MRA) between Philips
healthcare and CNIC. Drs García-Álvarez and Ibáñez are members
of the Spanish “Red de Investigación Cardiovascular” (RIC, RD
12/0042/0054). The CNIC is supported by the Spanish Ministry
of Economy and Competitiveness (MINECO) and the Pro-CNIC
Foundation and is a Severo Ochoa Center of Excellence (MINECO
award SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott Williams & Wilkins (LWW) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Magnetic Resonance Imaging, Cine | es_ES |
dc.subject.mesh | Pulmonary Circulation | es_ES |
dc.subject.mesh | Ventricular Function, Left | es_ES |
dc.subject.mesh | Ventricular Function, Right | es_ES |
dc.subject.mesh | Ventricular Remodeling | es_ES |
dc.subject.mesh | Adaptation, Physiological | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Biopsy | es_ES |
dc.subject.mesh | Cardiomyopathies | es_ES |
dc.subject.mesh | Disease Models, Animal | es_ES |
dc.subject.mesh | Disease Progression | es_ES |
dc.subject.mesh | Fibrosis | es_ES |
dc.subject.mesh | Hemodynamics | es_ES |
dc.subject.mesh | Hypertension, Pulmonary | es_ES |
dc.subject.mesh | Hypertrophy, Left Ventricular | es_ES |
dc.subject.mesh | Hypertrophy, Right Ventricular | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Myocardium | es_ES |
dc.subject.mesh | Predictive Value of Tests | es_ES |
dc.subject.mesh | Sus scrofa | es_ES |
dc.subject.mesh | Time Factors | es_ES |
dc.subject.mesh | Tomography, X-Ray Computed | es_ES |
dc.title | Magnetic Resonance Characterization of Cardiac Adaptation and Myocardial Fibrosis in Pulmonary Hypertension Secondary to Systemic-To-Pulmonary Shunt. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 27601365 | es_ES |
dc.format.volume | 9 | es_ES |
dc.format.number | 9 | es_ES |
dc.identifier.doi | 10.1161/CIRCIMAGING.116.004566 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1942-0080 | es_ES |
dc.relation.publisherversion | 10.1161/CIRCIMAGING.116.004566 | es_ES |
dc.identifier.journal | Circulation. Cardiovascular imaging | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI13/02339 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/TIN2012–37546-C03-02 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FPU/13/02662 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RD/12/0042/0054 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |