Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/18535
Título
Telomere shortening rate predicts species life span.
Autor(es)
Fecha de publicación
2019-07-23
Cita
Proc Natl Acad Sci U S A. 2019 ;116(30):15122-15127.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Telomere shortening to a critical length can trigger aging and shorter life spans in mice and humans by a mechanism that involves induction of a persistent DNA damage response at chromosome ends and loss of cellular viability. However, whether telomere length is a universal determinant of species longevity is not known. To determine whether telomere shortening can be a single parameter to predict species longevities, here we measured in parallel the telomere length of a wide variety of species (birds and mammals) with very different life spans and body sizes, including mouse (Mus musculus), goat (Capra hircus), Audouin's gull (Larus audouinii), reindeer (Rangifer tarandus), griffon vulture (Gyps fulvus), bottlenose dolphin (Tursiops truncatus), American flamingo (Phoenicopterus ruber), and Sumatran elephant (Elephas maximus sumatranus). We found that the telomere shortening rate, but not the initial telomere length alone, is a powerful predictor of species life span. These results support the notion that critical telomere shortening and the consequent onset of telomeric DNA damage and cellular senescence are a general determinant of species life span.
MESH
Telomere Shortening | Animals | Bottle-Nosed Dolphin | Cellular Senescence | Charadriiformes | Elephants | Falconiformes | Goats | Humans | Longevity | Mice | Regression Analysis | Reindeer | Species Specificity | Telomere
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