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dc.contributor.author | Whittemore, Kurt | |
dc.contributor.author | Martínez-Nevado, Eva | |
dc.contributor.author | Blasco, MA | |
dc.date.accessioned | 2024-02-20T12:42:39Z | |
dc.date.available | 2024-02-20T12:42:39Z | |
dc.date.issued | 2019-11-15 | |
dc.identifier.citation | Aging (Albany NY) . 2019 ;11(21):9829-9845. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/18533 | |
dc.description.abstract | Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phylogenetically distinct species from birds to mammals was lacking. Here, we demonstrate that the rate of accumulation of DNA damage as measured by the DNA damage marker γH2AX correlates with species longevity in dolphins, goats, reindeer, American flamingos, and griffon vultures. In particular, we find that species that show slower rates of accumulation of the DNA damage marker γH2AX also live longer. | es_ES |
dc.description.sponsorship | This Research was developed at Blasco lab, Spanish National Cancer Research Center, Institute of Health Carlos III, and is partially funded by the Spanish State Research Agency (AEI), Ministry of Science, Innovation and Universities, SAF2015-72455-EXP and SAF2013-45111-R, which is cofunded by EU-ERDF) and the Fundacion Botin (Spain). Partial funding was obtained from project CGL2016-80963-R (Ministerio Economia, Industria y Competividad). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Impact Journals | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | DNA Damage | es_ES |
dc.subject.mesh | Longevity | es_ES |
dc.subject.mesh | Vertebrates | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Birds | es_ES |
dc.subject.mesh | Bottle-Nosed Dolphin | es_ES |
dc.subject.mesh | Cross-Sectional Studies | es_ES |
dc.subject.mesh | Goats | es_ES |
dc.subject.mesh | Leukocytes | es_ES |
dc.subject.mesh | Reindeer | es_ES |
dc.subject.mesh | Turtles | es_ES |
dc.title | Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 31730540 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 21 | es_ES |
dc.format.page | 9829 | es_ES |
dc.identifier.doi | 10.18632/aging.102430 | es_ES |
dc.contributor.funder | Botín Foundation | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1945-4589 | es_ES |
dc.relation.publisherversion | https://doi.org/10.18632/aging.102430. | es_ES |
dc.identifier.journal | Aging | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.repisalud.orgCNIO | CNIO::Grupos de investigación::Grupo de Telómeros y Telomerasa | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/SAF2015-72455-EXP | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/SAF2013-45111-R | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/CGL2016-80963-R | es_ES |