Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/17959
Título
Cohesin in cancer: chromosome segregation and beyond.
Autor(es)
Losada, Ana CNIO | Losada, Ana CNIO
Fecha de publicación
2014-06
Cita
Nat Rev Cancer. 2014;14(6):389-93
Idioma
Inglés
Tipo de documento
journal article
Resumen
Cohesin is an evolutionarily conserved, four-subunit complex that entraps DNA fibres within its ring-shaped structure. It was originally identified and named for its role in mediating sister chromatid cohesion, which is essential for chromosome segregation and DNA repair. Increasing evidence indicates that cohesin participates in other processes that involve DNA looping, most importantly, transcriptional regulation. Mutations in genes encoding cohesin subunits and other regulators of the complex have recently been identified in several types of tumours. Whether aneuploidy that results from chromosome missegregation is the major contribution of cohesin mutations to cancer progression is under debate.
MESH
Chromosome Segregation | Gene Expression Regulation | Cell Cycle Proteins | Chromosomal Proteins, Non-Histone | DNA Repair | Humans | Neoplasms | Cohesins
Versión en línea
DOI
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