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dc.contributor.author | Murga, Matilde | |
dc.contributor.author | Fernandez-Capetillo, Oscar | |
dc.contributor.author | Tosato, Giovanna | |
dc.date.accessioned | 2024-02-09T16:25:12Z | |
dc.date.available | 2024-02-09T16:25:12Z | |
dc.date.issued | 2005-03-01 | |
dc.identifier.citation | Blood . 2005 ;105(5):1992-9. | es_ES |
dc.identifier.issn | 0006-4971 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/17799 | |
dc.description.abstract | Neuropilin-1 (NRP-1) is a type 1 membrane protein that binds the axon guidance factors belonging to the class-3 semaforin family. In endothelial cells, NRP-1 serves as a co-receptor for vascular endothelial growth factor (VEGF) and regulates VEGF receptor 2 (VEGFR-2)-dependent angiogenesis. Although gene-targeting studies documenting embryonic lethality in NRP-1 null mice have demonstrated a critical role for NRP-1 in vascular development, the activities of NRP-1 in mature endothelial cells have been incompletely defined. Using RNA interference-mediated silencing of NRP-1 or VEGFR-2 in primary human endothelial cells, we confirm that NRP-1 modulates VEGFR-2 signaling-dependent mitogenic functions of VEGF. Importantly, we now show that NRP-1 regulates endothelial cell adhesion to extracellular matrix proteins independently of VEGFR-2. Based on its dual role as an enhancer of VEGF activity and a mediator of endothelial cell adhesiveness described here, NRP-1 emerges as a promising molecular target for the development of antiangiogenic drugs. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Neovascularization, Physiologic | es_ES |
dc.subject.mesh | Cell Adhesion | es_ES |
dc.subject.mesh | Cell Movement | es_ES |
dc.subject.mesh | Cell Proliferation | es_ES |
dc.subject.mesh | Endothelium, Vascular | es_ES |
dc.subject.mesh | Extracellular Matrix Proteins | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Neuropilin-1 | es_ES |
dc.subject.mesh | RNA, Small Interfering | es_ES |
dc.subject.mesh | Receptors, CXCR4 | es_ES |
dc.subject.mesh | Umbilical Veins | es_ES |
dc.subject.mesh | Vascular Endothelial Growth Factor A | es_ES |
dc.subject.mesh | Vascular Endothelial Growth Factor Receptor-2 | es_ES |
dc.title | Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 15522955 | es_ES |
dc.format.volume | 105 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 1992 | es_ES |
dc.identifier.doi | 10.1182/blood-2004-07-2598 | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.1182/blood-2004-07-2598 | es_ES |
dc.identifier.journal | Blood | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.rights.accessRights | open access | es_ES |