Mostrar el registro sencillo del ítem
dc.contributor.author | Hernández-Barranco, Alberto | |
dc.contributor.author | Santos, Vanesa | |
dc.contributor.author | Mazariegos, Marina S | |
dc.contributor.author | Caleiras, Eduardo | |
dc.contributor.author | Nogués, Laura | |
dc.contributor.author | Mourcin, Frédéric | |
dc.contributor.author | Léonard, Simon | |
dc.contributor.author | Oblet, Christelle | |
dc.contributor.author | Genebrier, Steve | |
dc.contributor.author | Rossille, Delphine | |
dc.contributor.author | Benguría, Alberto | |
dc.contributor.author | Sanz, Alba | |
dc.contributor.author | Vázquez, Enrique | |
dc.contributor.author | Dopazo, Ana | |
dc.contributor.author | Efeyan, Alejo | |
dc.contributor.author | Ortega-Molina, Ana | |
dc.contributor.author | Cogne, Michel | |
dc.contributor.author | Tarte, Karin | |
dc.contributor.author | Peinado Selgas, Hector | |
dc.date.accessioned | 2024-02-07T11:20:54Z | |
dc.date.available | 2024-02-07T11:20:54Z | |
dc.date.issued | 2024-01-30 | |
dc.identifier.citation | Cell Rep . 2024 :113705. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/17534 | |
dc.description.abstract | Nerve growth factor receptor (NGFR) is expressed by follicular dendritic cells (FDCs). However, the role of NGFR in the humoral response is not well defined. Here, we study the effect of Ngfr loss on lymph node organization and function, demonstrating that Ngfr depletion leads to spontaneous germinal center (GC) formation and an expansion of the GC B cell compartment. In accordance with this effect, stromal cells are altered in Ngfr-/- mice with a higher frequency of FDCs, characterized by CD21/35, MAdCAM-1, and VCAM-1 overexpression. GCs are located ectopically in Ngfr-/- mice, with lost polarization together with impaired high-affinity antibody production and an increase in circulating autoantibodies. We observe higher levels of autoantibodies in Bcl2 Tg/Ngfr-/- mice, concomitant with a higher incidence of autoimmunity and lower overall survival. Our work shows that NGFR is involved in maintaining GC structure and function, participating in GC activation, antibody production, and immune tolerance. | es_ES |
dc.description.sponsorship | We apologize to those authors whose work could not be cited here due to the size limitations. We thank Dr. Miguel Angel Piris, Dr. Miguel Gallardo, Dr.Veronica Matı´a, Dr. Maria Jose´ Jime´ nez Santos, and all the members of the Microenvironment and Metastasis laboratory for their help in this project.This work was supported by project PID2020-118558RB-I00 (State Research MCIN/AEI/10.13039/501100011033), based on previous work funded by RETOS SAF2017-82924-R (MCIN/AEI/10.13039/501100011033 and cofounded by the European Regional Development fund [ERDF-EU]), and PDC2021-121102-I00 (MCIN/AEI/10.13039/501100011033, European Union ‘‘NextGenerationEU’’/PRTR). We thank ‘‘la Caixa’’ Foundation (fellow-ship ID100010434, LCF/BQ/DE17/11600007) and EMBO scientific exchange grant (number 9156) awarded to A.H.-B. The CNIO, certified as a Severo Ochoa Center of Excellence, is supported by the Spanish Government through the Instituto de Salud Carlos III (ISCIII). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | NGFR regulates stromal cell activation in germinal centers. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 38307025 | es_ES |
dc.format.page | 113705 | es_ES |
dc.identifier.doi | 10.1016/j.celrep.2024.113705 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2211-1247 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.celrep.2024.113705. | es_ES |
dc.identifier.journal | Cell reports | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.repisalud.orgCNIO | CNIO::Grupos de investigación::Grupo de Microambiente y Metástasis | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/SAF2017-82924-R | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PID2020-118558RB-I00 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033. | es_ES |