Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16812
Título
Clonal hematopoiesis and atherosclerotic cardiovascular disease: A primer.
Autor(es)
Zuriaga, María A | Fuster, Jose J. CNIC
Fecha de publicación
2023
Cita
Clin Investig Arterioscler. 2023 Jan-Feb;35(1):35-41.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Despite current standards of care, a considerable risk of atherosclerotic cardiovascular disease remains in both primary and secondary prevention. In this setting, clonal hematopoiesis driven by somatic mutations has recently emerged as a relatively common, potent and independent risk factor for atherosclerotic cardiovascular disease and other cardiovascular conditions. Experimental studies in mice suggest that mutations in TET2 and JAK2, which are among the most common in clonal hematopoiesis, increase inflammation and are causally connected to accelerated atherosclerosis development, which may explain the link between clonal hematopoiesis and increased cardiovascular risk. In this review, we provide an overview of our current understanding of this emerging cardiovascular risk factor.
MESH
Cardiovascular Diseases | Atherosclerosis | Animals | Mice | Clonal Hematopoiesis | Heart Disease Risk Factors | Inflammation | Mutation
Versión en línea
DOI
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