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dc.contributor.author | Fernández-Jiménez, Rodrigo | |
dc.contributor.author | García-Prieto, Jaime | |
dc.contributor.author | Sánchez-González, Javier | |
dc.contributor.author | Agüero, Jaume | |
dc.contributor.author | López-Martín, Gonzalo J | |
dc.contributor.author | Galán-Arriola, Carlos | |
dc.contributor.author | Molina-Iracheta, Antonio | |
dc.contributor.author | Doohan, Roisin | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Ibáñez, Borja | |
dc.date.accessioned | 2023-11-14T10:42:37Z | |
dc.date.available | 2023-11-14T10:42:37Z | |
dc.date.issued | 2015-08-18 | |
dc.identifier.citation | J Am Coll Cardiol. 2015 Aug 18;66(7):816-828. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16664 | |
dc.description.abstract | BACKGROUND Post-ischemia/reperfusion (I/R) myocardial edema was recently shown to follow a consistent bimodal pattern: an initial wave of edema appears on reperfusion and dissipates at 24 h, followed by a deferred wave that initiates days after infarction, peaking at 1 week. OBJECTIVES This study examined the pathophysiology underlying this post-I/R bimodal edematous reaction. METHODS Forty instrumented pigs were assigned to different myocardial infarction protocols. Edematous reaction was evaluated by water content quantification, serial cardiac magnetic resonance T2-mapping, and histology/immunohistochemistry. The association of reperfusion with the initial wave of edema was evaluated in pigs undergoing 40-min/80-min I/R and compared with pigs undergoing 120-min ischemia with no reperfusion. The role of tissue healing in the deferred wave of edema was evaluated by comparing pigs undergoing standard 40-min/7-day I/R with animals subjected to infarction without reperfusion (chronic 7-day coronary occlusion) or receiving post-I/R high-dose steroid therapy. RESULTS Characterization of post-I/R tissue changes revealed maximal interstitial edema early on reperfusion in the ischemic myocardium, with maximal content of neutrophils, macrophages, and collagen at 24 h, day 4, and day 7 post-I/R, respectively. Reperfused pigs had significantly higher myocardial water content at 120 min and T2 relaxation times on 120 min cardiac magnetic resonance than nonreperfused animals. Permanent coronary occlusion or high-dose steroid therapy significantly reduced myocardial water content on day 7 post-infarction. The dynamics of T2 relaxation times during the first post-infarction week were altered significantly in nonreperfused pigs compared with pigs undergoing regular I/R. CONCLUSIONS The 2 waves of the post-I/R edematous reaction are related to different pathophysiological phenomena. Although the first wave is secondary to reperfusion, the second wave occurs mainly because of tissue healing processes. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Edema | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Myocardial Ischemia | es_ES |
dc.subject.mesh | Myocardial Reperfusion | es_ES |
dc.subject.mesh | Myocardial Reperfusion Injury | es_ES |
dc.subject.mesh | Swine | es_ES |
dc.title | Pathophysiology Underlying the Bimodal Edema Phenomenon After Myocardial Ischemia/Reperfusion. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 26271065 | es_ES |
dc.format.volume | 66 | es_ES |
dc.format.number | 7 | es_ES |
dc.format.page | 816 | es_ES |
dc.identifier.doi | 10.1016/j.jacc.2015.06.023 | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1558-3597 | es_ES |
dc.relation.publisherversion | 10.1016/j.jacc.2015.06.023 | es_ES |
dc.identifier.journal | Journal of the American College of Cardiology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio de Imagen y Salud Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |