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dc.contributor.author | Fernández-Jiménez, Rodrigo | |
dc.contributor.author | Galán-Arriola, Carlos | |
dc.contributor.author | Sánchez-González, Javier | |
dc.contributor.author | Agüero, Jaume | |
dc.contributor.author | López-Martín, Gonzalo J | |
dc.contributor.author | Gomez-Talavera, Sandra | |
dc.contributor.author | Garcia-Prieto, Jaime | |
dc.contributor.author | Benn, Austin | |
dc.contributor.author | Molina-Iracheta, Antonio | |
dc.contributor.author | Barreiro-Pérez, Manuel | |
dc.contributor.author | Martin-García, Ana | |
dc.contributor.author | García-Lunar, Inés | |
dc.contributor.author | Pizarro, Gonzalo | |
dc.contributor.author | Sanz, Javier | |
dc.contributor.author | Sánchez, Pedro L | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Ibáñez, Borja | |
dc.date.accessioned | 2023-11-14T10:35:18Z | |
dc.date.available | 2023-11-14T10:35:18Z | |
dc.date.issued | 2017-08-04 | |
dc.identifier.citation | Circ Res. 2017 Aug 4;121(4):439-450. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16663 | |
dc.description.abstract | RATIONALE The impact of cardioprotective strategies and ischemia duration on postischemia/reperfusion (I/R) myocardial tissue composition (edema, myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, and microvascular obstruction) is not well understood. OBJECTIVE To study the effect of ischemia duration and protective interventions on the temporal dynamics of myocardial tissue composition in a translational animal model of I/R by the use of state-of-the-art imaging technology. METHODS AND RESULTS Four 5-pig groups underwent different I/R protocols: 40-minute I/R (prolonged ischemia, controls), 20-minute I/R (short-duration ischemia), prolonged ischemia preceded by preconditioning, or prolonged ischemia followed by postconditioning. Serial cardiac magnetic resonance (CMR)-based tissue characterization was done in all pigs at baseline and at 120 minutes, day 1, day 4, and day 7 after I/R. Reference myocardium at risk was assessed by multidetector computed tomography during the index coronary occlusion. After the final CMR, hearts were excised and processed for water content quantification and histology. Five additional healthy pigs were euthanized after baseline CMR as reference. Edema formation followed a bimodal pattern in all 40-minute I/R pigs, regardless of cardioprotective strategy and the degree of intramyocardial hemorrhage or microvascular obstruction. The hyperacute edematous wave was ameliorated only in pigs showing cardioprotection (ie, those undergoing short-duration ischemia or preconditioning). In all groups, CMR-measured edema was barely detectable at 24 hours postreperfusion. The deferred healing-related edematous wave was blunted or absent in pigs undergoing preconditioning or short-duration ischemia, respectively. CMR-measured infarct size declined progressively after reperfusion in all groups. CMR-measured myocardial salvage, and the extent of intramyocardial hemorrhage and microvascular obstruction varied dramatically according to CMR timing, ischemia duration, and cardioprotective strategy. CONCLUSIONS Cardioprotective therapies, duration of index ischemia, and the interplay between these greatly influence temporal dynamics and extent of tissue composition changes after I/R. Consequently, imaging techniques and protocols for assessing edema, myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, and microvascular obstruction should be standardized accordingly. | es_ES |
dc.description.sponsorship | This study was supported by a competitive grant from the Carlos III Institute of Health-Fondo de Investigacion Sanitaria and the European Regional Development Fund (ERDF/FEDER; PI10/02268 and PI13/01979), the Spanish Ministry of Economy, Industry, and Competitiveness (MEIC) and ERDF/FEDER (SAF2013-49663-EXP), and, in part, by the FP7-PEOPLE-2013-ITN Next generation training in cardiovascular research and innovation-Cardionext. R. FernándezJiménez holds a FICNIC fellowship from the Fundació Jesús Serra, the Fundación Interhospitalaria de Investigación Cardiovascular, and the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC). J. Agüero is a FP7-PEOPLE-2013-ITN-Cardionext fellow. This research program is part of an institutional agreement between FIIIS-Fundación Jiménez Díaz and CNIC. This study forms part of a Master Research Agreement between the CNIC and Philips Healthcare. This study is part of a bilateral research program between Hospital de Salamanca Cardiology Department and the CNIC. The CNIC is supported by the MEIC and the Pro CNIC Foundation and is supported by the MEIC and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (MEIC award SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott Williams & Wilkins (LWW) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Ischemic Preconditioning, Myocardial | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Multidetector Computed Tomography | es_ES |
dc.subject.mesh | Myocardial Infarction | es_ES |
dc.subject.mesh | Myocardial Ischemia | es_ES |
dc.subject.mesh | Myocardial Reperfusion | es_ES |
dc.subject.mesh | Swine | es_ES |
dc.subject.mesh | Time Factors | es_ES |
dc.title | Effect of Ischemia Duration and Protective Interventions on the Temporal Dynamics of Tissue Composition After Myocardial Infarction. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 28596216 | es_ES |
dc.format.volume | 121 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | 439 | es_ES |
dc.identifier.doi | 10.1161/CIRCRESAHA.117.310901 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Ministerio de Economía, Innovación y Competitividad (España) | es_ES |
dc.contributor.funder | Fundación Jesús Serra | es_ES |
dc.contributor.funder | Fundación Interhospitalaria de Investigación Cardiovascular | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1524-4571 | es_ES |
dc.relation.publisherversion | 10.1161/CIRCRESAHA.117.310901 | es_ES |
dc.identifier.journal | Circulation research | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio de Imagen y Salud Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/FP7-PEOPLE-2013-ITN | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI10/02268 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI13/01979 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SAF2013-49663-EXP | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MEIC/SEV-2015-0505 | es_ES |