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dc.contributor.author | Sanchez-Cabo, Fatima | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Silla-Castro, Juan Carlos | |
dc.contributor.author | González, Gema | |
dc.contributor.author | Lorenzo-Vivas, Erika | |
dc.contributor.author | Álvarez, Rebeca | |
dc.contributor.author | Callejas, Sergio | |
dc.contributor.author | Benguria, Alberto | |
dc.contributor.author | Gil, Eduardo | |
dc.contributor.author | Nunez, Estefania | |
dc.contributor.author | Oliva, Belen | |
dc.contributor.author | Mendiguren, José María | |
dc.contributor.author | Cortes-Canteli, Marta | |
dc.contributor.author | Bueno, Hector | |
dc.contributor.author | Andres, Vicente | |
dc.contributor.author | Ordovás, Jose María | |
dc.contributor.author | Fernandez-Friera, Leticia | |
dc.contributor.author | Quesada, Antonio J | |
dc.contributor.author | Garcia, Jose Manuel | |
dc.contributor.author | Rossello, Xavier | |
dc.contributor.author | Vazquez, Jesus | |
dc.contributor.author | Dopazo, Ana | |
dc.contributor.author | Fernández-Ortiz, Antonio | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Fuster, Jose Javier | |
dc.contributor.author | Lara-Pezzi, Enrique | |
dc.date.accessioned | 2023-09-05T09:21:13Z | |
dc.date.available | 2023-09-05T09:21:13Z | |
dc.date.issued | 2023-08-01 | |
dc.identifier.citation | Eur Heart J. 2023 Aug 1;44(29):2698-2709. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16410 | |
dc.description.abstract | AIMS Epigenetic age is emerging as a personalized and accurate predictor of biological age. The aim of this article is to assess the association of subclinical atherosclerosis with accelerated epigenetic age and to investigate the underlying mechanisms mediating this association. METHODS AND RESULTS Whole blood methylomics, transcriptomics, and plasma proteomics were obtained for 391 participants of the Progression of Early Subclinical Atherosclerosis study. Epigenetic age was calculated from methylomics data for each participant. Its divergence from chronological age is termed epigenetic age acceleration. Subclinical atherosclerosis burden was estimated by multi-territory 2D/3D vascular ultrasound and by coronary artery calcification. In healthy individuals, the presence, extension, and progression of subclinical atherosclerosis were associated with a significant acceleration of the Grim epigenetic age, a predictor of health and lifespan, regardless of traditional cardiovascular risk factors. Individuals with an accelerated Grim epigenetic age were characterized by an increased systemic inflammation and associated with a score of low-grade, chronic inflammation. Mediation analysis using transcriptomics and proteomics data revealed key pro-inflammatory pathways (IL6, Inflammasome, and IL10) and genes (IL1B, OSM, TLR5, and CD14) mediating the association between subclinical atherosclerosis and epigenetic age acceleration. CONCLUSION The presence, extension, and progression of subclinical atherosclerosis in middle-aged asymptomatic individuals are associated with an acceleration in the Grim epigenetic age. Mediation analysis using transcriptomics and proteomics data suggests a key role of systemic inflammation in this association, reinforcing the relevance of interventions on inflammation to prevent cardiovascular disease. | es_ES |
dc.description.sponsorship | The PESA study is co-funded by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain, and Banco Santander, Madrid, Spain. The study also receives funding from the Instituto de Salud Carlos III (PI15/02019, PI17/00590, and PI20/00819) and the European Regional Development Fund (ERDF) ‘Una manera de hacer Europa’. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MCIN/AEI/10.13039/501100011033). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Coronary Artery Disease | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Multiomics | es_ES |
dc.subject.mesh | Inflammation | es_ES |
dc.subject.mesh | Epigenesis, Genetic | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.title | Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 37339167 | es_ES |
dc.format.volume | 44 | es_ES |
dc.format.number | 29 | es_ES |
dc.format.page | 2698 | es_ES |
dc.identifier.doi | 10.1093/eurheartj/ehad361 | es_ES |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Agencia Nacional de Investigación e Innovación (Uruguay) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1522-9645 | es_ES |
dc.relation.publisherversion | 10.1093/eurheartj/ehad361 | es_ES |
dc.identifier.journal | European heart journal | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiaca | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI15/02019 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI17/00590 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI20/00819 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S/MCIN/AEI/10.13039/501100011033 | es_ES |