dc.contributor.author | Real, Carlos | |
dc.contributor.author | Párraga, Rocío | |
dc.contributor.author | Pizarro, Gonzalo | |
dc.contributor.author | García-Lunar, Inés | |
dc.contributor.author | González-Calvo, Ernesto | |
dc.contributor.author | Martínez-Gómez, Jesús | |
dc.contributor.author | Sánchez-González, Javier | |
dc.contributor.author | Sampedro, Patricia | |
dc.contributor.author | Sanmamed, Irene | |
dc.contributor.author | De Miguel, Mercedes | |
dc.contributor.author | De Cos-Gandoy, Amaya | |
dc.contributor.author | Bodega, Patricia | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Santos-Beneit, Gloria | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Fernández-Jiménez, Rodrigo | |
dc.date.accessioned | 2023-07-17T09:09:22Z | |
dc.date.available | 2023-07-17T09:09:22Z | |
dc.date.issued | 2023-03 | |
dc.identifier.citation | EClinicalMedicine. 2023 Mar 3;57:101885 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16258 | |
dc.description.abstract | BACKGROUND
Cardiovascular magnetic resonance (CMR) is a precise tool for the assessment of cardiac anatomy, function, and tissue composition. However, studies providing CMR reference values in adolescence are scarce. We aim to provide sex-specific CMR reference values for biventricular and atrial dimensions and function and myocardial relaxation times in this population.
METHODS
Adolescents aged 15-18 years with no known cardiovascular disease underwent a non-contrast 3-T CMR scan between March 2021 and October 2021. The imaging protocol included a cine steady-state free-precession sequence for the analysis of chamber size and function, as well as T2-GraSE and native MOLLI T1-mapping for the characterization of myocardial tissue.
FINDINGS
CMR scans were performed in 123 adolescents (mean age 16 ± 0.5 years, 52% girls). Mean left and right ventricular end-diastolic indexed volumes were higher in boys than in girls (91.7 ± 11.6 vs 78.1 ± 8.3 ml/m2, p < 0.001; and 101.3 ± 14.1 vs 84.1 ± 10.5 ml/m2, p < 0.001), as was the indexed left ventricular mass (48.5 ± 9.6 vs 36.6 ± 6.0 g/m2, p < 0.001). Left ventricular ejection fraction showed no significant difference by sex (62.2 ± 4.1 vs 62.8 ± 4.2%, p = 0.412), whereas right ventricular ejection fraction trended slightly lower in boys (55.4 ± 4.7 vs. 56.8 ± 4.4%, p = 0.085). Indexed atrial size and function parameters did not differ significantly between sexes. Global myocardial native T1 relaxation time was lower in boys than in girls (1215 ± 23 vs 1252 ± 28 ms, p < 0.001), whereas global myocardial T2 relaxation time did not differ by sex (44.4 ± 2.0 vs 44.1 ± 2.4 ms, p = 0.384). Sex-stratified comprehensive percentile tables are provided for most relevant cardiac parameters.
INTERPRETATION
This cross-sectional study provides overall and sex-stratified CMR reference values for cardiac dimensions and function, and myocardial tissue properties, in adolescents. This information is useful for clinical practice and may help in the differential diagnosis of cardiac diseases, such as cardiomyopathies and myocarditis, in this population.
FUNDING
Instituto de Salud Carlos III (PI19/01704). | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III (PI19/01704). The authors are indebted to the adolescents who participated in this
study. Rodrigo Fernández-Jiménez is recipient of grant PI19/01704 by
the Instituto de Salud Carlos III (ISCIII) - Fondo de Investigación Sanitaria
and the European Regional Development Fund/European Social Fund
(A way to make Europe/Investing in your future), which funded the
EnIGMA (Early ImaGing Markers of unhealthy lifestyles in Adolescents) study. Jesús Martínez-Gómez was a postgraduate fellow of the
Ministerio de Ciencia e Innovación at the Residencia de Estudiantes
(2020–2022) and is a recipient of grant FPU21/04891 (Ayudas para la
formación de profesorado universitario, FPU-2021) from the Ministerio de
Educación, Cultura y Deporte Gloria Santos-Beneit is recipient of grant
LCF/PR/MS19/12220001 funded by ““la Caixa” Foundation (ID
100010434). The SHE Foundation is supported by “la Caixa” Foundation
(LCF/PR/CE16/10700001). The CNIC is supported by the ISCIII, the
Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation
and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S
funded by MICIN/AEI/10.13039/501100011033). Simon Bartlett
(CNIC) provided English editing. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Magnetic resonance imaging reference values for cardiac morphology, function and tissue composition in adolescents. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 37064511 | es_ES |
dc.format.volume | 57 | es_ES |
dc.format.page | 101885 | es_ES |
dc.identifier.doi | 10.1016/j.eclinm.2023.101885 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Ministerio de Educación y Cultura (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2589-5370 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.eclinm.2023.101885 | es_ES |
dc.identifier.journal | EClinicalMedicine | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen y Salud Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI19/01704 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FPU21/04891 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/PR/MS19/12220001 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/100010434 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MICIN/AEI/10.13039/501100011033 | es_ES |