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dc.contributor.author | Tesoro, Laura | |
dc.contributor.author | Hernández, Ignacio | |
dc.contributor.author | Ramírez-Carracedo, Rafael | |
dc.contributor.author | Díez-Mata, Javier | |
dc.contributor.author | Alcharani, Nunzio | |
dc.contributor.author | Jiménez-Guirado, Beatriz | |
dc.contributor.author | Ovejero-Paredes, Karina | |
dc.contributor.author | Filice, Marco | |
dc.contributor.author | Zamorano, Jose Luis | |
dc.contributor.author | Saura, Marta | |
dc.contributor.author | Zaragoza, Carlos | |
dc.contributor.author | Botana, Laura | |
dc.date.accessioned | 2023-04-14T13:36:44Z | |
dc.date.available | 2023-04-14T13:36:44Z | |
dc.date.issued | 2022-09-26 | |
dc.identifier.citation | Pharmaceutics. 2022 Sep 26;14(10):2044 | es_ES |
dc.identifier.issn | 1999-4923 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15817 | |
dc.description.abstract | (1) Background: Early response after acute myocardial infarction (AMI) prevents extensive cardiac necrosis, in which inflammation resolution, including expression of anti-inflammatory interleukin-10 (IL-10), may play a key role. (2) Methods: We synthesized NIL10, a micelle-based nanoparticle, to target IL-10 receptor in mice and pigs subjected to AMI. (3) Results: Administration of NIL10 induced cardiac protection of wild-type and IL-10 knockout mice and pigs subjected to AMI. Cardiac protection was not induced in IL-10-receptor null mice, as shown by a significant recovery of cardiac function, in which inflammatory foci and fibrosis were strongly reduced, together with the finding that resolving M2-like macrophage populations were increased after day 3 of reperfusion. In addition, anti-inflammatory cytokines, including IL-4, IL-7, IL-10, IL-13, IL-16, and IL-27 were also elevated. Mechanistically, NIL10 induced activation of the IL-10 receptor/STAT-3 signaling pathway, and STAT3-dependent inhibition of nuclear translocation of pro-inflammatory NF-ĸB transcription factor. (4) Conclusions: Taken together, we propose using NIL10 as a novel therapeutic tool against AMI-induced cardiac damage. | es_ES |
dc.description.sponsorship | This research was funded by CZ: “Universidad Francisco de Vitoria (grant numbers 2017/18)”, “Proyectos de i+D+I, from the program Investigación orientada a los retos de la sociedad, cofounded by Fondo Europeo de Desarrollo Regional (FEDER) A way to achieve Europe (MINECO/AEI/FEDER/EU SAF2017-87342-R), (MICINN/AEI/FEDER/EU PID2020-118371RBI00)”, and “Proyectos de i+D+I, from the program Investigación orientada a los retos de la sociedad, cofounded by Fondo Europeo de Desarrollo Regional (FEDER) A way to achieve Europe PRUEBA DE CONCEPTO (MICINN/AEI/FEDER/EU PDC2021-121817-100); MS: “Ayudas para realización de proyectos de investigación Junta de Comunidades de Castilla La Mancha SBPLY/19/180501/000055, cofounded by Fondo Europeo de Desarrollo Regional (FEDER). A way to achieve Europe.”; MF: “Comunidad Autonoma de Madrid and Universidad Complutense de Madrid for research project No. 2017-T1/BIO-4992 Accion de Atracción de Talento”. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | NIL10: A New IL10-Receptor Binding Nanoparticle That Induces Cardiac Protection in Mice and Pigs Subjected to Acute Myocardial Infarction through STAT3/NF-κB Activation. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 36297479 | es_ES |
dc.format.volume | 14 | es_ES |
dc.format.number | 10 | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics14102044 | es_ES |
dc.contributor.funder | Francisco de Vitoria University (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Comunidad de Madrid (España) | es_ES |
dc.contributor.funder | Complutense University of Madrid (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/pharmaceutics14102044 | es_ES |
dc.identifier.journal | Pharmaceutics | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Microscopía | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2017/18 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MINECO/AEI/FEDER/EU SAF2017-87342-R | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MICINN/AEI/FEDER/EU PID2020-118371RBI00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SBPLY/19/180501/000055 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2017-T1/BIO-4992 | es_ES |