dc.contributor.author | Gonzalez-Franquesa, Alba | |
dc.contributor.author | Gama-Perez, Pau | |
dc.contributor.author | Kulis, Marta | |
dc.contributor.author | Szczepanowska, Karolina | |
dc.contributor.author | Dahdah, Norma | |
dc.contributor.author | Moreno-Gomez, Sonia | |
dc.contributor.author | Latorre-Pellicer, Ana | |
dc.contributor.author | Fernández-Ruiz, Rebeca | |
dc.contributor.author | Aguilar-Mogas, Antoni | |
dc.contributor.author | Hoffman, Anne | |
dc.contributor.author | Monelli, Erika | |
dc.contributor.author | Samino, Sara | |
dc.contributor.author | Miró-Blanch, Joan | |
dc.contributor.author | Oemer, Gregor | |
dc.contributor.author | Duran, Xavier | |
dc.contributor.author | Sanchez-Rebordelo, Estrella | |
dc.contributor.author | Schneeberger, Marc | |
dc.contributor.author | Obach, Merce | |
dc.contributor.author | Montane, Joel | |
dc.contributor.author | Castellano, Giancarlo | |
dc.contributor.author | Chapaprieta, Vicente | |
dc.contributor.author | Sun, Wenfei | |
dc.contributor.author | Navarro, Lourdes | |
dc.contributor.author | Prieto, Ignacio | |
dc.contributor.author | Castaño, Carlos | |
dc.contributor.author | Novials, Anna | |
dc.contributor.author | Gomis, Ramon | |
dc.contributor.author | Monsalve, Maria | |
dc.contributor.author | Claret, Marc | |
dc.contributor.author | Graupera, Mariona | |
dc.contributor.author | Soria, Guadalupe | |
dc.contributor.author | Wolfrum, Christian | |
dc.contributor.author | Vendrell, Joan | |
dc.contributor.author | Fernández-Veledo, Sonia | |
dc.contributor.author | Enriquez, Jose Antonio | |
dc.contributor.author | Carracedo, Angel | |
dc.contributor.author | Perales, José Carlos | |
dc.contributor.author | Nogueiras, Rubén | |
dc.contributor.author | Herrero, Laura | |
dc.contributor.author | Trifunovic, Aleksandra | |
dc.contributor.author | Keller, Markus A | |
dc.contributor.author | Yanes, Oscar | |
dc.contributor.author | Sales-Pardo, Marta | |
dc.contributor.author | Guimerà, Roger | |
dc.contributor.author | Blüher, Matthias | |
dc.contributor.author | Martín-Subero, José Ignacio | |
dc.contributor.author | Garcia-Roves, Pablo M | |
dc.date.accessioned | 2023-04-12T10:10:37Z | |
dc.date.available | 2023-04-12T10:10:37Z | |
dc.date.issued | 2022-08 | |
dc.identifier.citation | Redox Biol. 2022 Aug;54:102353 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15783 | |
dc.description.abstract | Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue. | es_ES |
dc.description.sponsorship | This work has been supported by Ministerio de Ciencia e Innovacion ´
(MICINN) Grant BFU2011- 24679 (P.M.G.-R.); Instituto de Salud Carlos
III (ISCIII) Grant PI15/00701 (P.M.G.-R.) cofinanced by the European
Regional Development Fund ‘‘A way to build Europe’‘; Government of
Catalonia Support Grups de Recerca AGAUR 2017-SGR-204 (to J.C.P.
and P.M.G-R.), 2017-SGR-736 (to J.I.M.-S.) and 2017-SGR-896 (to A.A.-
M., M.S.-P., and R.G.). M.M. was recipient of a MINECO grant RTI2018-
093864-B-I00. O.Y. was funded by MINECO grant BFU2017-87958. M.
A.K. was funded by a Medical University of Innsbruck Start Grant. M.C.
was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant
agreement 725004). L. H. was funded by MINECO grants SAF2013-
45887-R, SAF2017-83813-C3-1-R (granted to Dolors Serra (DS) and L.
H.), co-funded by the European Regional Development Fund, the Centro
de Investigacion ´ Biom´edica en Red de Fisiopatología de la Obesidad y la
Nutricion ´ (CIBEROBN) (Grant CB06/03/0001 to DS), the Government of
Catalonia (2017SGR278 to DS), the Fundacio ´ La Marato ´ de TV3
(201627–30 to DS), the European Foundation for the Study of Diabetes
(EFSD)/Janssen-Rising Star and L’Or´eal-UNESCO “For Women in Science” research fellowships. P.M.G.-R. was a recipient of a Ramon y Cajal
contract (RYC-2009-05158) from MICINN. A.G-F. was a recipient of
“Beca de Formacio ´ de Personal Investigador de l’IDIBAPS” fellowship
and she is currently supported by an unconditional donation from the
Novo Nordisk Foundation (NNF) to NNF Center for Basic Metabolic
Research (NNF18CC0034900). P.G-P. was a recipient of predoctoral
fellowship from the Universitat de Barcelona (APIF-UB). K.S was
financed through “Advanced Postdoc Grant” from SFB 1218 (DFG,
German Reuter Foundation, Projektnummer 269925409). J.M-B. was a
recipient of predoctoral fellowship from the European Union’s Horizon
2020 research and innovation program under the Marie SkłodowskaCurie grant agreement 675610. E.S-R. was recipient of a predoctoral
fellowship from Ministerio de Economia y Empresa (MINECO) grant
BES-2013-062796. This work was partially developed at the Esther
Koplowitz Center (CEK, Barcelona, Spain). We want to acknowledge the
following experts: Drs. Vidal-Puig A., Malagon M.M. and Raimundo N.
for their advice and critical discussion of our work. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Insulin Resistance | es_ES |
dc.subject.mesh | Adipose Tissue | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Homeostasis | es_ES |
dc.subject.mesh | Intra-Abdominal Fat | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Obesity | es_ES |
dc.subject.mesh | Proteomics | es_ES |
dc.title | Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 35777200 | es_ES |
dc.format.volume | 54 | es_ES |
dc.format.page | 102353 | es_ES |
dc.identifier.doi | 10.1016/j.redox.2022.102353 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Government of Catalonia (España) | es_ES |
dc.contributor.funder | Ministerio de Economía, Innovación y Competitividad (España) | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. H2020 | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBEROBN (Fisiopatología de la Obesidad y Nutrición) | es_ES |
dc.contributor.funder | Fundación La Marató TV3 | es_ES |
dc.contributor.funder | Novo Nordisk Foundation | es_ES |
dc.contributor.funder | Fundación Alicia Koplowitz | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2213-2317 | es_ES |
dc.relation.publisherversion | 10.1016/j.redox.2022.102353 | es_ES |
dc.identifier.journal | Redox biology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Genética Funcional del Sistema de Fosforilación Oxidativa | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/725004 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/BFU2011-24679 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI15/00701 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2017-SGR-204 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2017-SGR-736 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2017-SGR-896 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-093864-B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/BFU2017-87958 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SAF2013-45887-R | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SAF2017-83813-C3-1-R | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CB06/03/0001 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2017SGR278 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/201627–30 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RYC-2009-05158 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/BES-2013-062796 | es_ES |