dc.contributor.author | Laveriano-Santos, Emily P | |
dc.contributor.author | Quifer-Rada, Paola | |
dc.contributor.author | Marhuenda-Muñoz, María | |
dc.contributor.author | Arancibia-Riveros, Camila | |
dc.contributor.author | Vallverdú-Queralt, Anna | |
dc.contributor.author | Tresserra-Rimbau, Anna | |
dc.contributor.author | Ruiz-León, Ana María | |
dc.contributor.author | Casas, Rosa | |
dc.contributor.author | Estruch, Ramon | |
dc.contributor.author | Bodega, Patricia | |
dc.contributor.author | de Miguel, Mercedes | |
dc.contributor.author | de Cos-Gandoy, Amaya | |
dc.contributor.author | Martínez-Gómez, Jesús | |
dc.contributor.author | Santos-Beneit, Gloria | |
dc.contributor.author | Fernández-Alvira, Juan M | |
dc.contributor.author | Fernández-Jiménez, Rodrigo | |
dc.contributor.author | Lamuela-Raventós, Rosa M | |
dc.date.accessioned | 2023-04-11T14:18:41Z | |
dc.date.available | 2023-04-11T14:18:41Z | |
dc.date.issued | 2022-11-05 | |
dc.identifier.citation | Antioxidants (Basel). 2022 Nov 5;11(11):2191 | es_ES |
dc.identifier.issn | 2076-3921 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15763 | |
dc.description.abstract | (1) Background: To explore the association between microbial phenolic metabolites (MPM) and metabolic syndrome (MetS) and its clinical features in adolescents aged 12.02 ± 0.41 years. (2) Methods: a cross-sectional study was conducted in 560 participants at baseline in the SI! Program for Secondary Schools trial. The following MPM, coumaric acids (m-, o-, p-coumaric acids), dihydroxyphenylpropionic acid, dihydroresveratrol, enterolignans, gallic acid, hydroxybenzoic acids, hydroxyphenylacetic acid, hydroxytyrosol, protocatechuic acid, syringic acid, urolithins (A, B), and vanillic acid, were analyzed by HPLC-LTQ-Orbitrap-HRMS. MetS and its clinical features were defined in accordance with the International Diabetes Federation. (3) Results: Out of all MPM, urolithin A was inversely associated with the diastolic blood pressure z-score. Urolithin B was inversely associated with the MetS score and waist circumference z-score. Additionally, higher levels of gallic acid were associated with lower odds of presenting MetS (OR = 0.85, 95% CI: 0.77; 0.93) and abdominal obesity (OR = 0.93, 95% CI: 0.89; 0.98). Higher urolithin B levels were inversely associated with abdominal obesity (OR = 0.94, 95% CI: 0.89; 0.98) and high blood glucose (OR = 0.92, 95% CI:0.88; 0.96); (4) Conclusions: gallic acid, urolithin A and B were associated with lower odds of presenting MetS or some of its clinical features in adolescents. This is the first study that evaluates several MPM with MetS in adolescents, highlighting the importance of MPM on cardiometabolic health at early life stages. | es_ES |
dc.description.sponsorship | This study was supported within the framework of the SI! Program for Secondary Schools
trial from the SHE Foundation, and by the grant “la Caixa” Foundation (LCF/PR/CE16/10700001),
and the award of 369/C/2016 from Fundació la Marató de TV3. Grant was also provided by the
Ministerio de Ciencia, Innovación y Universidades (MCIN) (PID2020-114022RB-I00), Consorcio
CIBER, M.P. Fisiopatología de la Obesidad y Nutrición from the Instituto de Salud Carlos III (ISCIII)
and Generalitat de Catalunya. J.M.-G. is supported by the MCIN at the Residencia de Estudiantes
(2020–ongoing). R.F-J. is supported by the Fondo de Investigación Sanitaria- ISCIII (grant PI19/01704)
and co-funded by the European Regional Development Fund/European Social Fund “A way to
make Europe”/“Investing in your future” funded by The Centro Nacional de Investigaciones cardiovasculares (CNIC) from the ISCIII, the MCIN and the Pro CNIC Foundation, and is a Severo
Ochoa Center of Excellence (CEX2020-001041-S). G.S-B. is supported by “la Caixa” Foundation (ID
100010434) with the grant LCF/PR/MS19/12220001. A.T.-R. is a Serra Húnter Fellow. E.P.L.-S. is
supported by FI-SDUR (EMC/503/2021) fellowship program from the Generalitat de Catalunya.
Anna Vallverdú-Queralt is a recipient of a grant RYC-2016-19355 from the MCIN for the Ramon y
Cajal program. M.M.-M. is supported by the FPU17/00513 fellowship program. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Microbial Phenolic Metabolites in Urine Are Inversely Linked to Certain Features of Metabolic Syndrome in Spanish Adolescents. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 36358562 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 11 | es_ES |
dc.identifier.doi | 10.3390/antiox11112191 | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Fundación La Marató TV3 | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Government of Catalonia (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | 10.3390/antiox11112191 | es_ES |
dc.identifier.journal | Antioxidants (Basel, Switzerland) | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen y Salud Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/PR/CE16/10700001 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/369/C/2016 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2020-114022RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI19/01704 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/PR/MS19/12220001 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/EMC/503/2021 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RYC-2016-19355 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FPU17/00513 | es_ES |