dc.contributor.author | Val-Blasco, Almudena | |
dc.contributor.author | Prieto, Patricia | |
dc.contributor.author | Jaén, Rafael Iñigo | |
dc.contributor.author | Gil-Fernández, Marta | |
dc.contributor.author | Pajares, Marta | |
dc.contributor.author | Domenech, Nieves | |
dc.contributor.author | Terrón, Verónica | |
dc.contributor.author | Tamayo, María | |
dc.contributor.author | Jorge, Inmaculada | |
dc.contributor.author | Vazquez, Jesus | |
dc.contributor.author | Bueno-Sen, Andrea | |
dc.contributor.author | Vallejo-Cremades, María Teresa | |
dc.contributor.author | Pombo-Otero, Jorge | |
dc.contributor.author | Sanchez-García, Sergio | |
dc.contributor.author | Ruiz-Hurtado, Gema | |
dc.contributor.author | Gómez, Ana María | |
dc.contributor.author | Zaragoza, Carlos | |
dc.contributor.author | Crespo-Leiro, María Generosa | |
dc.contributor.author | López-Collazo, Eduardo | |
dc.contributor.author | Cuadrado, Antonio | |
dc.contributor.author | Delgado, Carmen | |
dc.contributor.author | Boscá, Lisardo | |
dc.contributor.author | Fernández-Velasco, María | |
dc.date.accessioned | 2023-04-11T11:44:24Z | |
dc.date.available | 2023-04-11T11:44:24Z | |
dc.date.issued | 2022-06 | |
dc.identifier.citation | JACC Basic Transl Sci. 2022 May 18; 7(6):544-560 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15753 | |
dc.description.abstract | Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage associated with myocarditis progression. The cardioprotective role of BML-111 is mainly caused by the prevention of increased oxidative stress and nuclear factor erythroid-derived 2-like 2 (NRF2) down-regulation induced by myocarditis. At the molecular level, BML-111 activates NRF2 signaling, which prevents sarcoplasmic reticulum-adenosine triphosphatase 2A down-regulation and Ca2+ mishandling, and attenuates the cardiac dysfunction and tissue damage induced by myocarditis. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and
Competitiveness and the European Regional Development Fund
(SAF-2017-84777R), Instituto de Salud Carlos III (ISCIII) (PI17/01093,
PI17/01344, and PI20/01482), Sociedad Española de Cardiología,
Proyecto Traslacional 2019 and Asociación del Ritmo Cardiaco (SEC,
España), Proyecto Asociación Insuficiencia Cardiaca (Trasplante Cardiaco) 2020, Fondo Europeo de Desarrollo Regional, Fondo Social
Europeo, and CIBERCV, a network funded by ISCIII, Spanish Ministry
of Science, Innovation and Universities (PGC2018-097019-B-I00),
Ministerio de Economía, Industria y Competitividad/Agencia Estatal
de Investigación 10.13039/501100011033 PID2020-113238RB-I00,
PID2019-105600RB-I00, the Instituto de Salud Carlos III (Fondo de
Investigación Sanitaria grant PRB3 [PT17/0019/0003-ISCIII-SGEFI/
ERDF, ProteoRed]), and “la Caixa” Foundation (project code HR17-
00247). The Centro Nacional de Investigaciones Cardiovasculares is
supported by the ISCIII, the Ministerio de Ciencia, Innovación y
Universidades. Dr Ruiz-Hurtado is Miguel Servet I researcher of ISCIII (CP15/00129 Carlos III Health Institute). Dr Tamayo and R.I. Jaén, and
M. Gil-Fernández were or currently are PhD students funded by the
Formación de Profesorado Universitario program of the Spanish
Ministry of Science, Innovation and Universities (FPU17/06135;
FPU16/00827, FPU1901973). The authors have reported that they have
no relationships relevant to the contents of this paper to disclose. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 35818504 | es_ES |
dc.format.volume | 7 | es_ES |
dc.format.number | 6 | es_ES |
dc.format.page | 544 | es_ES |
dc.identifier.doi | 10.1016/j.jacbts.2022.01.009 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Sociedad Española de Cardiología | es_ES |
dc.contributor.funder | Unión Europea. Fondo Social Europeo (ESF/FSE) | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares) | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2452-302X | es_ES |
dc.relation.publisherversion | 10.1016/j.jacbts.2022.01.009 | es_ES |
dc.identifier.journal | JACC. Basic to translational science | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Proteómica cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SAF-2017-84777R | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI17/01093 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI17/01344 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI20/01482 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PGC2018-097019-B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/10.13039/501100011033 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2020-113238RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2019-105600RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PT17/0019/0003-ISCIII-SGEFI | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR17-00247 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CP15/00129 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FPU17/06135 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FPU16/00827 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FPU1901973 | es_ES |