dc.contributor.author | Bernier-Latmani, Jeremiah | |
dc.contributor.author | Cisarovsky, Christophe | |
dc.contributor.author | Mahfoud, Samantha | |
dc.contributor.author | Ragusa, Simone | |
dc.contributor.author | Dupanloup, Isabelle | |
dc.contributor.author | Barras, David | |
dc.contributor.author | Renevey, François | |
dc.contributor.author | Nassiri, Sina | |
dc.contributor.author | Anderle, Pascale | |
dc.contributor.author | Squadrito, Mario Leonardo | |
dc.contributor.author | Siegert, Stefanie | |
dc.contributor.author | Davanture, Suzel | |
dc.contributor.author | González-Loyola, Alejandra | |
dc.contributor.author | Fournier, Nadine | |
dc.contributor.author | Luther, Sanjiv A | |
dc.contributor.author | Benedito, Rui | |
dc.contributor.author | Valet, Philippe | |
dc.contributor.author | Zhou, Bin | |
dc.contributor.author | De Palma, Michele | |
dc.contributor.author | Delorenzi, Mauro | |
dc.contributor.author | Sempoux, Christine | |
dc.contributor.author | Petrova, Tatiana V | |
dc.date.accessioned | 2023-04-11T10:20:12Z | |
dc.date.available | 2023-04-11T10:20:12Z | |
dc.date.issued | 2022-05 | |
dc.identifier.citation | Nat Cardiovasc Res. 2022 May;1(5):476-490 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15752 | |
dc.description.abstract | Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. VEGFA is a key driver of physiological and tumor angiogenesis. Accordingly, current anti-angiogenic cancer therapies target the VEGFA pathway. Here we report that in CRC expansion of the stem/progenitor pool in intestinal crypts requires VEGFA-independent growth and remodeling of blood vessels. Epithelial transformation induced expression of the endothelial peptide apelin, directs migration of distant venous endothelial cells towards progenitor niche vessels ensuring optimal perfusion. In the absence of apelin, loss of injury-inducible PROX1+ epithelial progenitors inhibited both incipient and advanced intestinal tumor growth. Our results establish fundamental principles for the reciprocal communication between vasculature and the intestinal progenitor niche and provide a mechanism for resistance to VEGFA-targeting drugs in CRCs. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Swiss Cancer League (KLS 3406-02-2016 and KFS-4895-08-2019), Foundation MEDIC, the Emma Muschamp Foundation, the Swiss National Science Foundation (31003A-156266 to TVP, 31003A-166161 to SAL), the European Research Council (ERC EVOLVE-725051 to MDP) and the Gabriela Kummer MD-PhD fellowship and Alfred and Anneliese Sutter-Stöttner private fellowships (to CC). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35602406 | es_ES |
dc.format.volume | 1 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 476 | es_ES |
dc.identifier.doi | 10.1038/s44161-022-00061-5 | es_ES |
dc.contributor.funder | Swiss National Science Foundation | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2731-0590 | es_ES |
dc.relation.publisherversion | 10.1038/s44161-022-00061-5 | es_ES |
dc.identifier.journal | Nature cardiovascular research | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Genética Molecular de la Angiogénesis | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/EVOLVE-725051 | es_ES |
dc.rights.accessRights | open access | es_ES |