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dc.contributor.authorRosina, Marco
dc.contributor.authorCeci, Veronica
dc.contributor.authorTurchi, Riccardo
dc.contributor.authorChuan, Li
dc.contributor.authorBorcherding, Nicholas
dc.contributor.authorSciarretta, Francesca
dc.contributor.authorSánchez-Díaz, María
dc.contributor.authorTortolici, Flavia
dc.contributor.authorKarlinsey, Keaton
dc.contributor.authorChiurchiù, Valerio
dc.contributor.authorFuoco, Claudia
dc.contributor.authorGiwa, Rocky
dc.contributor.authorField, Rachael L
dc.contributor.authorAudano, Matteo
dc.contributor.authorArena, Simona
dc.contributor.authorPalma, Alessandro
dc.contributor.authorRiccio, Federica
dc.contributor.authorShamsi, Farnaz
dc.contributor.authorRenzone, Giovanni
dc.contributor.authorVerri, Martina
dc.contributor.authorCrescenzi, Anna
dc.contributor.authorRizza, Salvatore
dc.contributor.authorFaienza, Fiorella
dc.contributor.authorFilomeni, Giuseppe
dc.contributor.authorKooijman, Sander
dc.contributor.authorRufini, Stefano
dc.contributor.authorde Vries, Antoine A F
dc.contributor.authorScaloni, Andrea
dc.contributor.authorMitro, Nico
dc.contributor.authorTseng, Yu-Hua
dc.contributor.authorHidalgo, Andres 
dc.contributor.authorZhou, Beiyan
dc.contributor.authorBrestoff, Jonathan R
dc.contributor.authorAquilano, Katia
dc.contributor.authorLettieri-Barbato, Daniele
dc.identifier.citationCell Metab. 2022 Apr 5;34(4):533-548.e12es_ES
dc.description.abstractRecent findings have demonstrated that mitochondria can be transferred between cells to control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a large component of the cell volume and undergo reorganization to sustain thermogenesis, it remains unclear whether an intercellular mitochondrial transfer occurs in brown adipose tissue (BAT) and regulates adaptive thermogenesis. Herein, we demonstrated that thermogenically stressed brown adipocytes release extracellular vesicles (EVs) that contain oxidatively damaged mitochondrial parts to avoid failure of the thermogenic program. When re-uptaken by parental brown adipocytes, mitochondria-derived EVs reduced peroxisome proliferator-activated receptor-γ signaling and the levels of mitochondrial proteins, including UCP1. Their removal via the phagocytic activity of BAT-resident macrophages is instrumental in preserving BAT physiology. Depletion of macrophages in vivo causes the abnormal accumulation of extracellular mitochondrial vesicles in BAT, impairing the thermogenic response to cold exposure. These findings reveal a homeostatic role of tissue-resident macrophages in the mitochondrial quality control of BAT.es_ES
dc.description.sponsorshipThis work was partially supported by the European Foundation for the Study of Diabetes (EFSD/Lilly, 2017 and EFSD/Boehringer Ingelheim European Research Programme on ‘‘Multi-System Challenges in Diabetes’’) and the Italian Ministry of Health (GR-2018-12367588) to D.L.-B.; Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG 2019 - ID. 23562 project to K.A.; MIUR ‘‘Progetto Eccellenza’’ to Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita` degli Studi di Milano, and NUTRAGE (CNR FOE 2019, DSB.AD004.271) to A.S; Italian Foundation of Multiple Sclerosis (grant 2017/R/8), the Italian Ministry of Health (grant GR-2016-02362380) and the MAI Award grant to V. Chiurchiu; National Institutes of Health (NIH) common fund (DP5 OD028125) and the Burroughs Wellcome Fund (1019648) to J.R.B.; NIH K01DK125608 to F.S.; R01DK102898 and R01DK122808 to Y.- H.T.; and NIH RO1 DK121805 and AHA 19TPA34910079 to B.Z. A.H. was supported by RTI2018-095497-B-I00 from MICINN, HR17_00527 from La Caixa Foundation, and TNE-18CVD04 from the Leducq Foundation. M.S-D was supported by a fellowship PRE2019-08746 from the Ministerio de Ciencia e Innovacio´ n. M.R. was partially supported by a fellowship from AIRC (IG 2019 - ID. 23562) and by the Italian Ministry of Health (SG-2019-12368589). V.C. is part of the PhD Program in Evolutionary Biology and Ecology, Department of Biology, University of Rome Tor Vergata.es_ES
dc.publisherCell Press es_ES
dc.subject.meshAdipose Tissue, Brown es_ES
dc.subject.meshThermogenesis es_ES
dc.subject.meshAdipocytes, Brown es_ES
dc.subject.meshMacrophages es_ES
dc.subject.meshMitochondria es_ES
dc.subject.meshUncoupling Protein 1 es_ES
dc.titleEjection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderEuropean Foundation for the Study of Diabetes es_ES
dc.contributor.funderBoehringer Ingelheim Fonds es_ES
dc.contributor.funderFondation Leducq es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España) es_ES
dc.contributor.funderFundación La Caixa es_ES
dc.identifier.journalCell metabolismes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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