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dc.contributor.authorSastre-Oliva, Tamara
dc.contributor.authorCorbacho-Alonso, Nerea
dc.contributor.authorAlbo-Escalona, Diego
dc.contributor.authorLopez, Juan A
dc.contributor.authorLopez-Almodovar, Luis F
dc.contributor.authorVazquez, Jesus 
dc.contributor.authorPadial, Luis R
dc.contributor.authorMourino-Alvarez, Laura
dc.contributor.authorBarderas, Maria G
dc.identifier.citationAntioxidants (Basel). 2022 Feb 5;11(2):317es_ES
dc.description.abstractCalcific aortic valve and coronary artery diseases are related cardiovascular pathologies in which common processes lead to the calcification of the corresponding affected tissue. Among the mechanisms involved in calcification, the oxidative stress that drives the oxidation of sulfur-containing amino acids such ascysteines is of particular interest. However, there are important differences between calcific aortic valve disease and coronary artery disease, particularly in terms of the reactive oxygen substances and enzymes involved. To evaluate what effect coronary artery disease has on aortic valves, we analyzed valve tissue from patients with severe calcific aortic stenosis with and without coronary artery disease. Proteins and peptides with oxidized cysteines sites were quantified, leading to the identification of 16 proteins with different levels of expression between the two conditions studied, as well as differences in the redox state of the tissue. We also identified two specific sites of cysteine oxidation in albumin that have not been described previously. These results provide evidence that coronary artery disease affects valve calcification, modifying the molecular profile of aortic valve tissue. In addition, the redox proteome is also altered when these conditions coincide, notably affecting human serum albumin.es_ES
dc.description.sponsorshipThis research was funded by the Junta de Comunidades de Castilla-La Mancha (JCCM, co-funded by the European Social Fund, SBPLY/19/180501/000226), the Instituto de Salud Carlos III through the project PI18/00995, PI21/00384 (co-funded by European Regional Development Fund/European Social Fund—“Investing in your future”) Sociedad Española de Cardiología, 2020, Grant PRB3 (IPT17/0019—ISCIII-SGEFI/ERDF), Spanish Ministry of Science, Innovation and Universities (PGC2018-097019-B-I00) and “la Caixa” Banking Foundation (project code HR17-00247). These results are aligned with the Spanish initiative on the Human Proteome Project (SpHPP).es_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.titleThe Influence of Coronary Artery Disease in the Development of Aortic Stenosis and the Importance of the Albumin Redox State.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderUnión Europea. Fondo Social Europeo (ESF/FSE) es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderSociedad Española de Cardiología es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) es_ES
dc.contributor.funderFundación La Caixa es_ES
dc.identifier.journalAntioxidants (Basel, Switzerland)es_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Proteómicaes_ES
dc.rights.accessRightsopen accesses_ES

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