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dc.contributor.author | Hong, Xiaotong | |
dc.contributor.author | Isern, Joan | |
dc.contributor.author | Campanario, Silvia | |
dc.contributor.author | Perdiguero, Eusebio | |
dc.contributor.author | Ramírez-Pardo, Ignacio | |
dc.contributor.author | Segalés, Jessica | |
dc.contributor.author | Hernansanz-Agustín, Pablo | |
dc.contributor.author | Curtabbi, Andrea | |
dc.contributor.author | Deryagin, Oleg | |
dc.contributor.author | Pollán, Angela | |
dc.contributor.author | González-Reyes, José A | |
dc.contributor.author | Villalba, José M | |
dc.contributor.author | Sandri, Marco | |
dc.contributor.author | Serrano, Antonio L | |
dc.contributor.author | Enriquez, Jose Antonio | |
dc.contributor.author | Muñoz-Cánoves, Pura | |
dc.date.accessioned | 2023-03-17T14:37:08Z | |
dc.date.available | 2023-03-17T14:37:08Z | |
dc.date.issued | 2022-09-01 | |
dc.identifier.citation | Cell Stem Cell. 2022 Sep 1;29(9):1298-1314.e10 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15674 | |
dc.description.abstract | Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem cells (satellite cells), a process that becomes less efficient with aging. Here, we show that mitochondrial dynamics are essential for the successful regenerative capacity of satellite cells. The loss of mitochondrial fission in satellite cells-due to aging or genetic impairment-deregulates the mitochondrial electron transport chain (ETC), leading to inefficient oxidative phosphorylation (OXPHOS) metabolism and mitophagy and increased oxidative stress. This state results in muscle regenerative failure, which is caused by the reduced proliferation and functional loss of satellite cells. Regenerative functions can be restored in fission-impaired or aged satellite cells by the re-establishment of mitochondrial dynamics (by activating fission or preventing fusion), OXPHOS, or mitophagy. Thus, mitochondrial shape and physical networking controls stem cell regenerative functions by regulating metabolism and proteostasis. As mitochondrial fission occurs less frequently in the satellite cells in older humans, our findings have implications for regeneration therapies in sarcopenia. | es_ES |
dc.description.sponsorship | We thank J. M. Ballesteros, L. Ortet, V. Lukesova, E. Andre´ s, V. Moiseeva, A. Navarro, and M. Raya for their technical contributions, L. Garcı´a-Prat for initiating satellite cell/mitophagy studies, and all members of the P.M.C. laboratory for their helpful discussions. We are very grateful to L. Scorrano for the Drp1-floxed (and Opa1-floxed) mouse lines and for reading the manuscript, V. Romanello for help in obtaining mouse lines, F. Sa´ nchez-Cabo and M. J. Go´ - mez for assistance in bioinformatics, and R.I. Klein Geltink and E. Pearce for advice on 3D mitochondria analysis; we also thank M.B. Alvarez-Flores and E. Prieto-Garcı´a (CNIC FACS Facility); V. Caiolfa and V. Labrador-Cantarero (CNIC Advanced Microscopy Facility); A. Dopazo and A. Benguria (CNIC-Genomics Facility); S. Rodrı´guez-Colilla (CNIC-Animal Facility); and Myoage network and tissue bank and Hospital Vall d’Hebron, for human material. We are also indebted to Veronica Raker for excellent editing. Work in the PMC laboratory was supported by Spanish Ministerio de Ciencia e Innovacio´ n (RTI2018-096068 to P.M.-C. and E.P), ERC-2016-AdG-741966, LaCaixa- HEALTH-HR17-00040, MDA, UPGRADE-H2020-825825, AFM-Telethon, DPP-Spain, Fundacio´ La Marato´ TV3-80/19-202021 to P.M.-C; Fundacio´ La Marato´ TV3-137/38-202033 to A.L.S.; partly supported by Milky Way Research Foundation (MWRF) to P.M.-C; Severo Ochoa Program for Centers of Excellence to CNIC (SEV-2015-0505) and Maria de Maeztu Program for Units of Excellence to UPF (MDM-2014-0370). Work in the JAE laboratory was supported by Ministerio de Ciencia e Innovacion (RTI2018-099357-BI00, RED2018-102576-T), Human Frontier Science Program HFSP (RGP0016/2018), Centro de Investigacio´ n Biome´ dica en Red en Fragilidad y Envejecimento Saludable (CIBERFES16/10/00282), and Leduq Foundation award (REDOX-17CVD04). Work in JMV laboratory was supported by the Spanish Ministerio de Ciencia e Innovacio´ n (RTI2018-100695-B-I00), Spanish Junta de Andalucı´a (P18-RT-4264, 1263735-R and BIO-276), the FEDER Funding Program from the European Union, and Universidad de Co´ rdoba. The authors are indebted to the personnel from the Servicio Centralizado de Apoyo a la Investigacio´ n (SCAI; University of Co´ rdoba) for technical support with the transmission electron microscope. Work in MS laboratory was funded by the Italian Assoc. for Cancer Research (AIRC IG-D17388 and ID23257) and ASI (MARS-PRE, project DC-VUM-2017-006). X.H., S.C., I.R.-P, and A.C were supported by Severo Ochoa PFI, PI, FPI, and H2020 Marie Sk1odowska-Curie Actions predoctoral fellowships, respectively. P.H.-A was supported by Juan de la Cierva-Incorporacio´ n fellowship. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Mitochondrial Dynamics | es_ES |
dc.subject.mesh | Mitophagy | es_ES |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Mitochondria | es_ES |
dc.subject.mesh | Muscle, Skeletal | es_ES |
dc.subject.mesh | Muscles | es_ES |
dc.subject.mesh | Stem Cells | es_ES |
dc.title | Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 35998641 | es_ES |
dc.format.volume | 29 | es_ES |
dc.format.number | 9 | es_ES |
dc.format.page | 1298 | es_ES |
dc.identifier.doi | 10.1016/j.stem.2022.07.009 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Fundación La Marató TV3 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Regional Government of Andalusia (España) | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. H2020 | es_ES |
dc.contributor.funder | Marie Curie | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1875-9777 | es_ES |
dc.relation.publisherversion | 10.1016/j.stem.2022.07.009 | es_ES |
dc.identifier.journal | Cell stem cell | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Genética Funcional del Sistema de Fosforilación Oxidativa | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-096068 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/TV3-80/19-202021 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-099357-BI00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RED2018-102576-T | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RGP0016/2018 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-100695-B-I00 | es_ES |