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dc.contributor.authorLaveriano-Santos, Emily P
dc.contributor.authorArancibia-Riveros, Camila
dc.contributor.authorParilli-Moser, Isabella
dc.contributor.authorRamírez-Garza, Sonia L
dc.contributor.authorTresserra-Rimbau, Anna
dc.contributor.authorRuiz-León, Ana María
dc.contributor.authorEstruch, Ramón
dc.contributor.authorBodega, Patricia 
dc.contributor.authorde Miguel, Mercedes 
dc.contributor.authorde Cos-Gandoy, Amaya 
dc.contributor.authorCarral, Vanesa
dc.contributor.authorSantos-Beneit, Gloria 
dc.contributor.authorFernández-Alvira, Juan M
dc.contributor.authorFernández-Jiménez, Rodrigo
dc.contributor.authorLamuela-Raventós, Rosa M
dc.date.accessioned2023-03-17T12:52:50Z
dc.date.available2023-03-17T12:52:50Z
dc.date.issued2022-09-14
dc.identifier.citationSci Rep. 2022 Sep 14;12(1):15468es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15672
dc.description.abstractTo study the relationship between urinary total polyphenol excretion (TPE) in adolescents and ideal cardiovascular (CVH) metrics. 1151 adolescents aged 12.04 (0.46) years participating in the SI! Program for Secondary Schools were selected based on the availability of urine samples and information required to assess CVH metrics. Data on health behaviours (smoking status, body mass index, physical activity, and healthy diet) and health factors (blood pressure, total cholesterol, and blood glucose) were used to calculate the CVH metrics. TPE in urine was analysed by a Folin-Ciocalteu method after solid-phase extraction. Associations between TPE (categorized into tertiles) and CVH metrics (total and separate scores) were assessed using multilevel mixed-effect regression models. Higher TPE levels were associated with higher (healthier) CVH scores and ideal smoking status (OR 1.54, 95% CI 1.10; 1.87, p value = 0.007), physical activity (OR 1.12, 95% CI 1.02; 1.23, p value = 0.022) and total cholesterol (OR 1.78, 95% CI 1.16; 2.73, p value = 0.009) after multivariate adjustment. An association between TPE and total CVH scores was observed only in boys. Girls with higher TPE had higher rates of ideal total cholesterol and blood pressure. According to our findings, higher urinary TPE is related to better CVH scores, with relevant differences in this association by gender.es_ES
dc.description.sponsorshipThe authors wish to thank all the volunteers and their families, teachers, and schools for their contribution to the SI! Program for Secondary Schools. The SI! Program for Secondary Schools trial was supported by the SHE Foundation, the “la Caixa” Foundation (grant numbers LCF/PR/CE16//10700001 and LCF/PR/MS19/12220001), and the Fundació la Marató de TV3 (grant number 369/C/2016). Support was also provided by the Ministerio de Ciencia, Innovación y Universidades (grant number AGL2016–75329-R), and Generalitat de Catalunya. Rodrigo Fernández-Jiménez is a recipient of grant PI19/01704 funded by the Fondo de Investigación Sanitaria- Instituto de Salud Carlos III (ISCIII) and co-funded by the European Regional Development Fund/European Social Fund "A way to make Europe"/"Investi ng in your future". The Centro Nacional de Investigaciones Cardiovasculares is supported by the ISCIII, the Ministerio de Ciencia e Innovación, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (CEX2020-001041-S). Anna Tresserra-Rimbau was supported by a Serra Húnter Fellowship. Emily P. Laveriano-Santos is thankful for the FI-SDUR (EMC/3345/2020) fellowship from the Generalitat de Catalunya. Isabella Parilli-Moser thanks the FI-SDUR (EMC/2703/2019) fellowship.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshCardiovascular Diseases es_ES
dc.subject.meshPolyphenols es_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshCholesterol es_ES
dc.subject.meshCross-Sectional Studies es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshQuality Indicators, Health Carees_ES
dc.titleTotal urinary polyphenols and ideal cardiovascular health metrics in Spanish adolescents enrolled in the SI Program: a cross-sectional study.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID36104478es_ES
dc.format.volume12es_ES
dc.format.number1es_ES
dc.format.page15468es_ES
dc.identifier.doi10.1038/s41598-022-19684-6es_ES
dc.contributor.funderFundación La Caixa es_ES
dc.contributor.funderFundación La Marató TV3 es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España) es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) es_ES
dc.contributor.funderFundación ProCNIC es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/369/C/2016es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/CEX2020-001041-Ses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/EMC/2703/2019es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/EMC/3345/2020es_ES


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