dc.contributor.author | Cómitre-Mariano, Blanca | |
dc.contributor.author | Martínez-García, Magdalena | |
dc.contributor.author | García-Gálvez, Bárbara | |
dc.contributor.author | Paternina-Die, María | |
dc.contributor.author | Desco, Manuel | |
dc.contributor.author | Carmona, Susanna | |
dc.contributor.author | Gómez-Gaviro, María Victoria | |
dc.date.accessioned | 2023-03-17T10:46:30Z | |
dc.date.available | 2023-03-17T10:46:30Z | |
dc.date.issued | 2022-01-21 | |
dc.identifier.citation | iScience. 2021 Dec 29;25(1):103664 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15664 | |
dc.description.abstract | There is a bidirectional transplacental cell trafficking between mother and fetus during pregnancy in placental mammals. The presence and persistence of fetal cells in maternal tissues are known as fetal microchimerism (FMc). FMc has high multilineage potential with a great ability to differentiate and functionally integrate into maternal tissue. FMc has been found in various maternal tissues in animal models and humans. Its permanence in the maternal body up to decades after delivery suggests it might play an essential role in maternal pathophysiology. Studying the presence, localization, and characteristics of FMc in maternal tissues is key to understanding its impact on the woman's body. Here we comprehensively review the existence of FMc in different species and organs and tissues, aiming to better characterize their possible role in human health and disease. We also highlight several methodological considerations that would optimize the detection, quantification, and functional determination of FMc. | es_ES |
dc.description.sponsorship | This work was supported by Ministerio de Ciencia e Innovación project RTI2018-093952-B-100 and by Instituto de Salud Carlos III projects CP16/00096, PI18/00462 and PI17/00064, and co-funded by European
Regional Development Fund (ERDF), A way to make Europe. MMG was funded by Ministerio de Ciencia
e Innovación, Instituto de Salud Carlos III, Predoctorales de Formación en Investigación en Salud (PFIS)
(contract FI18/00255) and a predoctoral Fulbright grant. BC was supported by Consejería de Educación
e Investigación, Comunidad de Madrid, co-funded by European Social Fund ‘‘Investing in your future’’
(PEJD-2019-PRE/BMD-16977). SC was funded by a Miguel Servet Type I research contract (CP16/00096).
MM-G and SC were co-funded by European Social Fund Investing in your future. The project leading to
these results has received funding from la Caixa Foundation under the project code LCF/PR/HR19/
52160001, from the European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation programme (grant agreement No 883069), and from the Centro Nacional de Investigaciones Cardiovasculares (CNIC). The CNIC is supported by Instituto de Salud Carlos III (ISCIII), Ministerio
de Ciencia e Innovación and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV2015-050). We thank Vicente Llorente Úbeda for reading the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Feto-maternal microchimerism: Memories from pregnancy. | es_ES |
dc.type | review | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 35072002 | es_ES |
dc.format.volume | 25 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 103664 | es_ES |
dc.identifier.doi | 10.1016/j.isci.2021.103664 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | US-UK Fulbright Commission | es_ES |
dc.contributor.funder | Comunidad de Madrid (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. Horizonte Europa | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2589-0042 | es_ES |
dc.relation.publisherversion | 10.1016/j.isci.2021.103664 | es_ES |
dc.identifier.journal | iScience | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Imagen Avanzada | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/883069 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-093952-B-100 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CP16/00096 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI18/00462 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI17/00064 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FI18/00255 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PEJD-2019-PRE/BMD-16977 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/e LCF/PR/HR19/52160001 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SEV2015-050 | es_ES |