dc.contributor.author | Soto-Montenegro, Mª Luisa | |
dc.contributor.author | García-Vázquez, Verónica | |
dc.contributor.author | Lamanna-Rama, Nicolás | |
dc.contributor.author | López-Montoya, Gonzalo | |
dc.contributor.author | Desco, Manuel | |
dc.contributor.author | Ambrosio, Emilio | |
dc.date.accessioned | 2023-03-16T09:16:06Z | |
dc.date.available | 2023-03-16T09:16:06Z | |
dc.date.issued | 2022-03-17 | |
dc.identifier.citation | Sci Rep. 2022 Mar 17;12(1):4643 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15636 | |
dc.description.abstract | Vulnerability to addiction may be given by the individual's risk of developing an addiction during their lifetime. A challenge in the neurobiology of drug addiction is understanding why some people become addicted to drugs. Here, we used positron emission tomography (PET) and statistical parametric mapping (SPM) to evaluate changes in brain glucose metabolism in response to chronic morphine self-administration (MSA) in two rat strains with different vulnerability to drug abuse, Lewis (LEW) and Fischer 344 (F344). Four groups of animals were trained to self-administer morphine or saline for 15 days. 2-deoxy-2-[18F]-fluoro-D-glucose (FDG)-PET studies were performed on the last day of MSA (acquisition phase) and after 15 days of withdrawal. PET data were analyzed using SPM12. LEW-animals self-administered more morphine injections per session than F344-animals. We found significant brain metabolic differences between LEW and F344 strains in the cortex, hypothalamus, brainstem, and cerebellum. In addition, the different brain metabolic patterns observed after the MSA study between these rat strains indicate differences in the efficiency of neural substrates to translate the drug effects, which could explain the differences in predisposition to morphine abuse between one individual and another. These findings have important implications for the use of these rat strains in translational morphine and opiate research. | es_ES |
dc.description.sponsorship | MLS was supported by the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (projects PI17/01766,
and grant BA21/00030), co-funded by the European Regional Development Fund (ERDF), “A way to make
Europe”, CIBERSAM, Delegación del Gobierno para el Plan Nacional sobre Drogas (2017/085), Fundación
Mapfre, and Fundación Alicia Koplowitz. EA was supported by grants from Ministerio de Sanidad, Servicios
Sociales e Igualdad and Red de Trastornos Adictivos del Instituto de Salud Carlos III (RTA-RD16/020/0022),
Delegación del Gobierno para el Plan Nacional sobre Drogas (2016I073), Ministerio de Ciencia e Innovación
(PSI2016-80541-P), UNED (Plan de Promoción de la Investigación 2018–2020), and the European Union´s
Justice Programme – Drugs Policy Initiatives (JUST-2017-AG-DRUGS- 806996-JUSTSO). NLR was supported
by Instituto de Investigación Sanitaria Gregorio Marañón, "Programa Intramural de Impulso a la I + D + I
2019″. MD work was supported by Ministerio de Ciencia e Innovación (MCIN) and Insituto de Salud Carlos
III (ISCIII) (PT20/00044). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio
de Ciencia e Innovación (MCIN), and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence
(SEV‐2015‐0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Glucose | es_ES |
dc.subject.mesh | Morphine | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Brain | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Neuroimaging | es_ES |
dc.subject.mesh | Rats | es_ES |
dc.subject.mesh | Rats, Inbred F344 | es_ES |
dc.subject.mesh | Rats, Inbred Lew | es_ES |
dc.subject.mesh | Species Specificity | es_ES |
dc.subject.mesh | Tomography, X-Ray Computed | es_ES |
dc.title | Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35301397 | es_ES |
dc.format.volume | 12 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 4643 | es_ES |
dc.identifier.doi | 10.1038/s41598-022-08698-9 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Fundación Mapfre | es_ES |
dc.contributor.funder | Fundación Alicia Koplowitz | es_ES |
dc.contributor.funder | Plan Nacional de Drogas (España) | es_ES |
dc.contributor.funder | Ministerio de Sanidad, Servicios Sociales e Igualdad (España) | es_ES |
dc.contributor.funder | RETICS-Transtornos Adictivos (RTA-ISCIII) (España) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Unión Europea | es_ES |
dc.contributor.funder | Instituto de Investigación Sanitaria Gregorio Marañón | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | National University of Distance Education (España) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.relation.publisherversion | 10.1038/s41598-022-08698-9 | es_ES |
dc.identifier.journal | Scientific reports | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Imagen Avanzada | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/JUST-2017-AG-DRUGS- 806996-JUSTSO | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI17/01766 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/BA21/00030 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTA-RD16/020/0022 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PSI2016-80541-P | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PT20/00044 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/SEV‐2015‐0505 | es_ES |