Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15348
Título
Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development.
Autor(es)
Fecha de publicación
2021-11-12
Cita
Sci Adv. 2021 Nov 12;7(46):eabj5445. Epub 2021 Nov 12.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Mutations in the G protein–coupled receptor GPR126/ADGRG6 cause human diseases, including defective peripheral nervous system (PNS) myelination. To study GPR126 function, we generated new genetic mice and zebrafish models. Murine Gpr126 is expressed in developing heart endocardium, and global Gpr126 inactivation is embryonically lethal, with mutants having thin-walled ventricles but unaffected heart patterning or maturation. Endocardial-specific Gpr126 deletion does not affect heart development or function, and transgenic endocardial GPR126 expression fails to rescue lethality in Gpr126-null mice. Zebrafish gpr126 mutants display unaffected heart development. Gpr126 is also expressed in placental trophoblast giant cells. Gpr126-null mice with a heterozygous placenta survive but exhibit GPR126-defective PNS phenotype. In contrast, Gpr126-null embryos with homozygous mutant placenta die but are rescued by placental GPR126 expression. Gpr126-deficient placentas display down-regulation of preeclampsia markers Mmp9, Cts7, and Cts8. We propose that the placenta-heart axis accounts for heart abnormalities secondary to placental defects in Gpr126 mutants.
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- Adhesion G protein_coupled ...
- Tamaño:
- 18.68Mb
- Formato:
- Descripción:
- Artículo