dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Fernández-Ortiz, Antonio | |
dc.contributor.author | Fernández-Friera, Leticia | |
dc.contributor.author | García-Lunar, Inés | |
dc.contributor.author | Andres, Vicente | |
dc.contributor.author | Fuster, Valentin | |
dc.date.accessioned | 2022-11-21T11:13:03Z | |
dc.date.available | 2022-11-21T11:13:03Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | J Am Coll Cardiol . 2021 Jul 13;78(2):156-179. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15205 | |
dc.description.abstract | Atherosclerosis starts early in life and progresses silently for decades. Considering atherosclerosis as a "systemic disease" invites the use of noninvasive methodologies to detect disease in various regions before symptoms appear. The PESA-(Progression of Early Subclinical Atherosclerosis) CNIC-SANTANDER study is an ongoing prospective cohort study examining imaging, biological, and behavioral parameters associated with the presence and progression of early subclinical atherosclerosis. Between 2010 and 2014, PESA enrolled 4,184 asymptomatic middle-aged participants who undergo serial 3-yearly follow-up examinations including clinical interviews, lifestyle questionnaires, sampling, and noninvasive imaging assessment of multiterritorial subclinical atherosclerosis (carotids, iliofemorals, aorta, and coronaries). PESA tracks the trajectories of atherosclerosis and associated disorders from early stages to the transition to symptomatic phases. A joint venture between the CNIC and the Santander Bank, PESA is expected to run until at least 2029, and its significant contributions to date are presented in this review paper. | es_ES |
dc.description.sponsorship | The PESA study is funded by the CNIC and Santander Bank. The study
has also received funding from the Carlos III Institute of Health
(ISCIII, PI15/02019, PI17/00590, and PI20/00819) and the European
Regional Development Fund. The CNIC is supported by the ISCIII, the
MICIN, and the Pro CNIC Foundation. Dr Ibanez is the recipient of a
European Research Council grant MATRIX (ERC-COG-2018-ID:
819775). Dr Andrés is supported by grant PID2019-108489RB-I00 from
the Spanish Ministerio de Ciencia e Innovación (MICIN), with
cofunding from the European Regional Development Fund/Fondo
Europeo de Desarrollo Regional (ERDF/FEDER, “A way to build
Europe”). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Arteries | es_ES |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Disease Progression | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Longitudinal Studies | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Plaque, Atherosclerotic | es_ES |
dc.subject.mesh | Tomography, X-Ray Computed | es_ES |
dc.subject.mesh | Ultrasonography | es_ES |
dc.title | Progression of Early Subclinical Atherosclerosis (PESA) Study: JACC Focus Seminar 7/8. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 34238438 | es_ES |
dc.format.volume | 78 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | 156-179 | es_ES |
dc.identifier.doi | 10.1016/j.jacc.2021.05.011 | es_ES |
dc.contributor.funder | Banco Santander | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1558-3597 | es_ES |
dc.relation.publisherversion | 10.1016/j.jacc.2021.05.011 | es_ES |
dc.identifier.journal | Journal of the American College of Cardiology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genética | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/819775/EU | |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2015). Modalidad proyectos en salud. (2015)/PI15/02019 | |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI17 - Proyectos de investigacion en salud (AES 2017). Modalidad proyectos en salud. (2017)/PI17/00590 | |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/Subprograma Estatal de Generación de Conocimiento/PI20 - Proyectos de investigacion en salud (AES 2020). Modalidad proyectos de investigación en salud. (2020)/PI20/00819 | |