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dc.contributor.author | Fernández-Gallego, Nieves | |
dc.contributor.author | Castillo-González, Raquel | |
dc.contributor.author | Méndez-Barbero, Nerea | |
dc.contributor.author | López-Sanz, Celia | |
dc.contributor.author | Obeso, David | |
dc.contributor.author | Villaseñor, Alma | |
dc.contributor.author | Escribese, María M | |
dc.contributor.author | López-Melgar, Beatriz | |
dc.contributor.author | Salamanca, Jorge | |
dc.contributor.author | Benedicto-Buendía, Amparo | |
dc.contributor.author | Jiménez-Borreguero, Luis Jesús | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Sastre, Joaquín | |
dc.contributor.author | Belver, María Teresa | |
dc.contributor.author | Vega, Francisco | |
dc.contributor.author | Blanco, Carlos | |
dc.contributor.author | Barber, Domingo | |
dc.contributor.author | Sánchez-Madrid, Francisco | |
dc.contributor.author | de la Fuente, Hortensia | |
dc.contributor.author | Martin, Pilar | |
dc.contributor.author | Esteban, Vanesa | |
dc.contributor.author | Jiménez-Saiz, Rodrigo | |
dc.contributor.author | Fernández‐Gallego, Nieves | |
dc.contributor.author | Castillo‐González, Raquel | |
dc.contributor.author | Méndez‐Barbero, Nerea | |
dc.contributor.author | López‐Sanz, Celia | |
dc.contributor.author | Escribese, María M. | |
dc.contributor.author | López‐Melgar, Beatriz | |
dc.contributor.author | Benedicto‐Buendía, Amparo | |
dc.contributor.author | Jiménez‐Borreguero, Luis Jesús | |
dc.contributor.author | Sánchez‐Madrid, Francisco | |
dc.contributor.author | Jiménez‐Saiz, Rodrigo | |
dc.date.accessioned | 2022-11-15T11:22:25Z | |
dc.date.available | 2022-11-15T11:22:25Z | |
dc.date.issued | 2022-11 | |
dc.identifier.citation | Allergy . 2022 Nov;77(11):3249-3266. | es_ES |
dc.identifier.issn | 0105-4538 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15143 | |
dc.description.abstract | Allergic diseases are allergen-induced immunological disorders characterized by the development of type 2 immunity and IgE responses. The prevalence of allergic diseases has been on the rise alike cardiovascular disease (CVD), which affects arteries of different organs such as the heart, the kidney and the brain. The underlying cause of CVD is often atherosclerosis, a disease distinguished by endothelial dysfunction, fibrofatty material accumulation in the intima of the artery wall, smooth muscle cell proliferation, and Th1 inflammation. The opposed T-cell identity of allergy and atherosclerosis implies an atheroprotective role for Th2 cells by counteracting Th1 responses. Yet, the clinical association between allergic disease and CVD argues against it. Within, we review different phases of allergic pathology, basic immunological mechanisms of atherosclerosis and the clinical association between allergic diseases (particularly asthma, atopic dermatitis, allergic rhinitis and food allergy) and CVD. Then, we discuss putative atherogenic mechanisms of type 2 immunity and allergic inflammation including acute allergic reactions (IgE, IgG1, mast cells, macrophages and allergic mediators such as vasoactive components, growth factors and those derived from the complement, contact and coagulation systems) and late phase inflammation (Th2 cells, eosinophils, type 2 innate-like lymphoid cells, alarmins, IL-4, IL-5, IL-9, IL-13 and IL-17). | es_ES |
dc.description.sponsorship | Severo Ochoa Center of Excellence, Grant/Award Number: CEX2020-001041- S; Pro CNIC Foundation; Ministerio de Ciencia e Innovación; Ministry of Science and Innovation, Grant/ Award Number: PID2019-110369RB- I00; European Commission, Grant/Award Number: ERC-CoG 819775 and H2020-HEALTH 945118; Spanish Ministry of Universities; Ayudas Margarita Salas para la Formación de Jóvenes Doctores—Universidad Autónoma de Madrid, Grant/ Award Number: CA1/RSUE/2021–00577; Formación de Profesorado Universitario, Grant/Award Number: FPU16/03953; Sociedad Española de Alergología e Inmunología Clínica (SEAIC), Grant/ Award Number: BECA20A9; New Frontiers in Research Fund, Grant/ Award Number: NFRFE-2019- 00083; The Nutricia Research Foundation, Grant/Award Number: NRF-2021- 13; Instituto de Salud Carlos III, Grant/Award Number: PI21/00158, PI21/01126, CP20/00043, PI18/01467, PI19/00044, RD16/0006/0015 and RD21/0002/0008; Severo Ochoa Program, Grant/Award Number: AEI/SEV-2017- 0712 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Rhinitis, Allergic | es_ES |
dc.subject.mesh | Atherosclerosis | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Cytokines | es_ES |
dc.subject.mesh | Th2 Cells | es_ES |
dc.subject.mesh | Immunoglobulin E | es_ES |
dc.subject.mesh | Inflammation | es_ES |
dc.title | The impact of type 2 immunity and allergic diseases in atherosclerosis. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35781885 | es_ES |
dc.format.volume | 77 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | 3249-3266 | es_ES |
dc.identifier.doi | 10.1111/all.15426. Epub 2022 Jul 18. | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Ministerio de Universidades (España) | es_ES |
dc.contributor.funder | Autonomous University of Madrid (España) | es_ES |
dc.contributor.funder | Sociedad Española de Alergología e Inmunología Clínica | es_ES |
dc.contributor.funder | Frontiers Foundation | es_ES |
dc.contributor.funder | Nutricia Research Foundation | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1398-9995 | es_ES |
dc.relation.publisherversion | DOI: 10.1111/all.15426 | es_ES |
dc.identifier.journal | Allergy | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC-CoG-819775 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/HEALTH-945118 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/NFRFE-2019-00083 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/NRF-2021-13 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2019-110369RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CA1/RSUE/2021–00577 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FPU16/03953 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI21/00158 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI21/01126 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CP20/00043 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI18/01467 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI19/00044 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RD16/0006/0015 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RD21/0002/0008 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/AEI/SEV-2017-0712 | es_ES |