Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15139
Título
Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages.
Autor(es)
Fecha de publicación
2018
Cita
Circ Res . 2018 Feb 16;122(4):583-590. doi: 10.1161/CIRCRESAHA.117.311490. Epub 2017 Dec 21.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Myocardial infarction is a major cause of adult mortality worldwide. The origin(s) of cardiac fibroblasts that constitute the postinfarct scar remain controversial, in particular the potential contribution of bone marrow lineages to activated fibroblasts within the scar.
The aim of this study was to establish the origin(s) of infarct fibroblasts using lineage tracing and bone marrow transplants and a robust marker for cardiac fibroblasts, the Collagen1a1-green fluorescent protein reporter.
Using genetic lineage tracing or bone marrow transplant, we found no evidence for collagen-producing fibroblasts derived from hematopoietic or bone marrow lineages in hearts subjected to permanent left anterior descending coronary artery ligation. In fact, fibroblasts within the infarcted area were largely of epicardial origin. Intriguingly, collagen-producing fibrocytes from hematopoietic lineages were observed attached to the epicardial surface of infarcted and sham-operated hearts in which a suture was placed around the left anterior descending coronary artery.
In this controversial field, our study demonstrated that the vast majority of infarct fibroblasts were of epicardial origin and not derived from bone marrow lineages, endothelial-to-mesenchymal transition, or blood. We also noted the presence of collagen-producing fibrocytes on the epicardial surface that resulted at least in part from the surgical procedure.
MESH
Cell Lineage | Animals | Bone Marrow Cells | Bone Marrow Transplantation | Cells, Cultured | Collagen Type I | Mice | Mice, Inbred C57BL | Myocardial Infarction | Myofibroblasts | Pericardium
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