dc.contributor.author | Delgado-Arévalo, Cristina | |
dc.contributor.author | Calvet-Mirabent, Marta | |
dc.contributor.author | Triguero-Martinez, Ana | |
dc.contributor.author | Vázquez de Luis, Enrique | |
dc.contributor.author | Benguría-Filippini, Alberto | |
dc.contributor.author | Largo, Raquel | |
dc.contributor.author | Calzada-Fraile, Diego | |
dc.contributor.author | Popova, Olga | |
dc.contributor.author | Sánchez-Cerrillo, Ildefonso | |
dc.contributor.author | Tsukalov, Ilya | |
dc.contributor.author | Moreno-Vellisca, Roberto | |
dc.contributor.author | de la Fuente, Hortensia | |
dc.contributor.author | Herrero-Beaumont, Gabriel | |
dc.contributor.author | Ramiro, Almudena R | |
dc.contributor.author | Sánchez-Madrid, Francisco | |
dc.contributor.author | Castañeda, Santos | |
dc.contributor.author | Dopazo, Ana | |
dc.contributor.author | González-Álvaro, Isidoro | |
dc.contributor.author | Martin-Gayo, Enrique | |
dc.date.accessioned | 2022-11-14T13:10:36Z | |
dc.date.available | 2022-11-14T13:10:36Z | |
dc.date.issued | 2022-10-04 | |
dc.identifier.citation | JCI Insight . 2022 Oct 4;e152886. doi: 10.1172/jci.insight.152886. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15128 | |
dc.description.abstract | The individual contribution of specific myeloid subsets such as CD1c+ conventional dendritic cells (cDC) to perpetuation of Rheumatoid Arthritis (RA) pathology remains unclear. In addition, the specific innate sensors driving pathogenic activation of CD1c+ cDCs in RA patients and their functional implications have not been characterized. Here, we assessed phenotypical, transcriptional and functional characteristics of CD1c+ and CD141+ cDCs and monocytes from the blood and synovial fluid of RA patients. Increased levels of CCR2 and the IgG receptor CD64 on circulating CD1c+ cDC associated with the presence of this DC subset in the synovial membrane in RA patients. Moreover, synovial CD1c+ cDCs are characterized by increased expression of proinflammatory cytokines and high abilities to induce pathogenic IFNγ+IL-17+ CD4+ T cells in vitro. Finally, we identified the crosstalk between Fcγ Receptors and NLRC4 as a new potential molecular mechanism mediating pathogenic activation, CD64 upregulation and functional specialization of CD1c+ cDCs in response to dsDNA-IgG in RA patients. | es_ES |
dc.description.sponsorship | E.M.G. was supported by Comunidad de Madrid Talento Program (2017-T1/BMD5396), Ramón y Cajal Program (RYC2018-024374-I), the MINECO RETOS program
(RTI2018-097485-A-I00), La Caixa Foundation (HR20-00218), CIBERINF (CB21/13/00107) and the TV3 Marató (REDINCOV). C.D.A. was supported by
Comunidad de Madrid Talento Program (2017-T1/BMD-5396). M.C.M was supported
by the NIH (R21AI140930). HR17-00016 grant from “La Caixa Banking Foundation to
F.S.M also supported the study. D.C-F. is supported by the Fellowship “la Caixa”
Foundation LCF/BQ/DR19/11740010. A.T.M. was supported by a PhD fellowship from
the Autonomous Region of Madrid (PEJD-2019-PRE/BMD-16851) and the
RD21/0002/0027 grant. R.L. and G.H.B. were supported by PI18/00261 AND
PI20/00349 grants from Ministerio de Ciencia e Innovación and Instituto de Salud Carlos
III, respectively. O.P. was supported by the TV3 Marató (REDINCOV) and I.T. was
funded by grant for the promotion of research studies master-UAM 2021. S.C. was
supported by PI21/01474 grant from the Instituto de Salud Carlos III and co-funded by
The European Regional Development Fund (ERDF). I.G.A was supported by
RD21/0002/0027 and PI21/00526 grants from the Spanish MINECO and Instituto de
Salud Carlos III and co-funded by The European Regional Development Fund (ERDF)
“A way to make Europe. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Clinical Investigation (ASCI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | NLRC4 -mediated activation of CD1c+ dendritic cells contributes to perpetuation of synovitis in rheumatoid arthritis. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 36194479 | es_ES |
dc.identifier.doi | 10.1172/jci.insight.152886 | es_ES |
dc.contributor.funder | Comunidad de Madrid (España) | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Fundación La Marató TV3 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2379-3708 | es_ES |
dc.relation.publisherversion | DOI: 10.1172/jci.insight.152886 | es_ES |
dc.identifier.journal | JCI insight | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas:: Unidad de Genómica | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2017-T1/BMD5396 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RYC2018-024374-I | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-097485-A-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR20-00218 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CB21/13/00107 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/REDINCOV | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2017-T1/BMD-5396 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR17-00016 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/BQ/DR19/11740010 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PEJD-2019-PRE/BMD-16851 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RD21/0002/0027 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI18/00261 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI20/00349 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI21/00526 | es_ES |