Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/14774
Título
The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer.
Autor(es)
Fecha de publicación
2018-05-18
Cita
Cell Cycle . 2018;17(6):702-711.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The transcriptional repressor Capicua (CIC) has emerged as an important rheostat of cell growth regulated by RAS/MAPK signaling. Cic was originally discovered in Drosophila, where it was shown to be inactivated by MAPK signaling downstream of the RTKs Torso and EGFR, which results in signal-dependent responses that are required for normal cell fate specification, proliferation and survival of developing and adult tissues. CIC is highly conserved in mammals, where it is also negatively regulated by MAPK signaling. Here, we review the roles of CIC during mammalian development, tissue homeostasis, tumor formation and therapy resistance. Available data indicate that CIC is involved in multiple biological processes, including lung development, liver homeostasis, autoimmunity and neurobehavioral processes. Moreover, CIC has been shown to be involved in tumor development as a tumor suppressor, both in human as well as in mouse models. Finally, several lines of evidence implicate CIC as a determinant of sensitivity to EGFR and MAPK pathway inhibitors, suggesting that CIC may play a broader role in human cancer than originally anticipated.
MESH
Signal Transduction | Animals | Drosophila | Drug Resistance, Neoplasm | Gene Expression Regulation, Developmental | Humans | Neoplasms | Protein Isoforms | Repressor Proteins | ras Proteins
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DOI
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