Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/14686
Título
Implications of mitochondrial DNA mutations in human induced pluripotent stem cells.
Autor(es)
Fecha de publicación
2021-11-02
Cita
Nat Rev Genet. 2021.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Individual cells in the same induced pluripotent stem cell (iPSC)-derived clones can exhibit large heterogeneity. In this Comment, Carelli et al. discuss emerging evidence implicating variants in mitochondrial DNA, and highlight the need for routine screening of iPSCs.
Single-cell analyses in recent years have shown major differences in the transcriptome between individual cells in the same induced pluripotent stem cell-derived clones. Although these differences are in part attributable to genetic and epigenetic modifications of the nuclear genome, emerging evidence suggests that variants in mitochondrial DNA also play a pivotal role.
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DOI
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