Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/13712
The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders
Porcuna, Jesus CNIC | Mínguez-Martínez, Jorge | Ricote, Mercedes CNIC
Int J Mol Sci. 2021 Oct; 22(19): 10573
Peroxisome proliferator-activated receptors (PPARs) are ligand-modulated nuclear receptors that play pivotal roles in nutrient sensing, metabolism, and lipid-related processes. Correct control of their target genes requires tight regulation of the expression of different PPAR isoforms in each tissue, and the dysregulation of PPAR-dependent transcriptional programs is linked to disorders, such as metabolic and immune diseases or cancer. Several PPAR regulators and PPAR-regulated factors are epigenetic effectors, including non-coding RNAs, epigenetic enzymes, histone modifiers, and DNA methyltransferases. In this review, we examine advances in PPARα and PPARγ-related epigenetic regulation in metabolic disorders, including obesity and diabetes, immune disorders, such as sclerosis and lupus, and a variety of cancers, providing new insights into the possible therapeutic exploitation of PPAR epigenetic modulation.
Epigenesis, Genetic | Animals | DNA Methylation | Gene Expression Regulation | Humans | Immune System Diseases | Metabolic Diseases | Neoplasms | PPAR alpha | PPAR gamma
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