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dc.contributor.author | López Grondona, Fermín | |
dc.contributor.author | Rodriguez, Laura | |
dc.contributor.author | Mansilla, E | |
dc.contributor.author | Martinez-Fernandez, Maria Luisa | |
dc.contributor.author | Martínez-Frías, María Luisa | |
dc.date.accessioned | 2022-02-22T11:27:24Z | |
dc.date.available | 2022-02-22T11:27:24Z | |
dc.date.issued | 2004-10 | |
dc.identifier.citation | Boletín del ECEMC: Rev Dismor Epidemiol 2004; V (nº 3): 18-24 | es_ES |
dc.identifier.issn | 0210–3893 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/13696 | |
dc.description | Dismorfología, Citogenética y Clínica: Resultados de estudios sobre los datos del ECEMC | es_ES |
dc.description.abstract | Here we present two unrelated cases that came to our service for families that are looking for information on the diagnostic on malformation syndromes and infants with congenital defects. Both cases show as common signs psychomotor delay, microcephaly, corpus callosum agenesis and inespecific facial phenotype. We perform a high resolution G-bands karyotypes, and both of them showed a "de novo" deletion in the proximal region of a chromosome 14, with different break points but with a common region deleted. The karyotype of the first case was 46,XY, del(14)(q12;q21.1), and the karyotype of the second case 46,XX del(14)(q11.2;q13.1). We discussed the possible candidates genes that could be related with the phenotype and review the different reported cases. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Instituto de Salud Carlos III (ISCIII). Instituto de Investigación de Enfermedades Raras (IIER) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Dismorfología | es_ES |
dc.subject | Anomalías congénitas | es_ES |
dc.subject | Epidemiología | es_ES |
dc.title | Deleción 14q proximal, presentación de dos casos y revisión de la literatura | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.format.volume | V | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | 18-24 | es_ES |
dc.description.peerreviewed | No | es_ES |
dc.identifier.journal | Boletín del ECEMC: Revista de Dismorfología y Epidemiología | es_ES |
dc.repisalud.centro | ISCIII | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |