Show simple item record

dc.contributor.authorRollín, Raquel
dc.contributor.authorTornero-Esteban, Pilar
dc.contributor.authorMarco, Fernando
dc.contributor.authorCamafeita, Emilio 
dc.contributor.authorCalvo, Enrique 
dc.contributor.authorLópez-Durán, Luis
dc.contributor.authorJover, Juan Ángel
dc.contributor.authorLopez, Juan Antonio 
dc.contributor.authorLamas, José Ramón
dc.contributor.authorFernandez-Gutierrez, Benjamin
dc.date.accessioned2021-02-23T09:38:45Z
dc.date.available2021-02-23T09:38:45Z
dc.date.issued2008-08
dc.identifier.citationJ Proteomics Bioinform. 2008; 1:267-80es_ES
dc.identifier.issn0974-276X
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11969
dc.description.abstractCartilage damage is a major problem in osteoarthritis (OA). To gain insight into the pathogenesis of OA, we have analyzed the differential proteome of articular chondrocytes from these patients. Protein extracts were prepared from cultured chondrocytes from 6 patients with end-stage OA and 6 normal donors and were analyzed by 2D-DIGE. Differentially expressed proteins were identified by mass spectrometry (MS). Significant differential expression was observed for 27 proteins, with 14 underexpressed and 13 overexpressed chondrocyte OA proteins. Of special interest was the identification of destrin, cofilins, gelsolin, annexin A2, glycolytic enzymes, chaperones, cathepsin D, proteasome beta 9 subunit isoform 2 proprotein and proteasome activator hPA28 subunit beta. The altered expression of these proteins is consistent with events such as cytoskeleton binding, protein disruption, apoptosis, and glycolysis, demonstrating the ability of the 2D-DIGE/MS platform to identify proteins with altered expression in chondrocytes from patients with end-stage OA. The identification of these proteins may open new lines of research for this disease.es_ES
dc.language.isoenges_ES
dc.publisherLongdom Group SAes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleDifferential Proteome of Articular Chondrocytes From Patients with Osteoarthritises_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.format.volume01es_ES
dc.format.number05es_ES
dc.format.page267-280es_ES
dc.identifier.doi10.4172/jpb.1000034es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.4172/jpb.1000034es_ES
dc.identifier.journalJournal of Proteomics & Bioinformaticses_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Proteómica / Metabolómicaes_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Files in this item

Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional