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dc.contributor.authorArques, Carlos G
dc.contributor.authorDoohan, Roisin
dc.contributor.authorSharpe, James
dc.contributor.authorTorres, Miguel 
dc.date.accessioned2021-02-17T09:21:32Z
dc.date.available2021-02-17T09:21:32Z
dc.date.issued2007-10
dc.identifier.citationDevelopment. 2007; 134(20):3713-22es_ES
dc.identifier.issn0950-1991
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11920
dc.description.abstractRegionalization of embryonic fields into independent units of growth and patterning is a widespread strategy during metazoan development. Compartments represent a particular instance of this regionalization, in which unit coherence is maintained by cell lineage restriction between adjacent regions. Lineage compartments have been described during insect and vertebrate development. Two common characteristics of the compartments described so far are their occurrence in epithelial structures and the presence of signaling regions at compartment borders. Whereas Drosophila compartmental organization represents a background subdivision of embryonic fields that is not necessarily related to anatomical structures, vertebrate compartment borders described thus far coincide with, or anticipate, anatomical or cell-type discontinuities. Here, we describe a general method for clonal analysis in the mouse and use it to determine the topology of clone distribution along the three limb axes. We identify a lineage restriction boundary at the limb mesenchyme dorsoventral border that is unrelated to any anatomical discontinuity, and whose lineage restriction border is not obviously associated with any signaling center. This restriction is the first example in vertebrates of a mechanism of primordium subdivision unrelated to anatomical boundaries. Furthermore, this is the first lineage compartment described within a mesenchymal structure in any organism, suggesting that lineage restrictions are fundamental not only for epithelial structures, but also for mesenchymal field patterning. No lineage compartmentalization was found along the proximodistal or anteroposterior axes, indicating that patterning along these axes does not involve restriction of cell dispersion at specific axial positions.es_ES
dc.language.isoenges_ES
dc.publisherThe Company of Biologistses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshBody Patterning es_ES
dc.subject.meshCell Lineage es_ES
dc.subject.meshEmbryo, Mammalianes_ES
dc.subject.meshLimb Buds es_ES
dc.subject.meshMesoderm es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHomeodomain Proteins es_ES
dc.subject.meshLIM-Homeodomain Proteins es_ES
dc.subject.meshMale es_ES
dc.subject.meshMice es_ES
dc.subject.meshMice, Transgenic es_ES
dc.subject.meshPregnancy es_ES
dc.subject.meshTranscription Factors es_ES
dc.titleCell tracing reveals a dorsoventral lineage restriction plane in the mouse limb bud mesenchyme.es_ES
dc.typeArtículoes_ES
dc.identifier.pubmedID17715176es_ES
dc.format.volume134es_ES
dc.format.number20es_ES
dc.format.page3713-22es_ES
dc.identifier.doi10.1242/dev.02873es_ES
dc.contributor.funderMinisterio de Educación y Ciencia (España)es_ES
dc.contributor.funderHuman Frontier Science Program - HFSPes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Sanidad y Consumo (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1242/dev.02873es_ES
dc.identifier.journalDevelopment (Cambridge, England)es_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Control Genético del Desarrollo y Regeneración de Órganoses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2006-10978/BMCes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/RGP0008/2004es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/LSHG-CT-2003-5032259es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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