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dc.contributor.authorLopez-Melgar, Beatriz 
dc.contributor.authorFernandez-Friera, Leticia 
dc.contributor.authorSanchez-Gonzalez, Javier 
dc.contributor.authorVilchez, Jean Paul 
dc.contributor.authorCecconi, Alberto
dc.contributor.authorMateo, Jesus 
dc.contributor.authorPeñalvo, Jose L 
dc.contributor.authorOliva, Belen 
dc.contributor.authorGarcia-Ruiz, Jose M 
dc.contributor.authorKauffman, Steve
dc.contributor.authorJimenez-Borreguero, Luis J. 
dc.contributor.authorRuiz-Cabello, Jesus 
dc.contributor.authorFernandez-Ortiz, Antonio 
dc.contributor.authorIbáñez, Borja 
dc.contributor.authorFuster, Valentin 
dc.date.accessioned2021-02-12T11:10:43Z
dc.date.available2021-02-12T11:10:43Z
dc.date.issued2016-05
dc.identifier.citationAtherosclerosis. 2016; 248:230-237es_ES
dc.identifier.issn0021-9150
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11871
dc.description.abstractDirect quantification of atherosclerotic plaque volume by three-dimensional vascular ultrasound (3DVUS) is more reproducible than 2DUS-based three-dimensional (2D/3D) techniques that generate pseudo-3D volumes from summed 2D plaque areas; however, its accuracy has not been reported. We aimed to determine 3DVUS accuracy for plaque volume measurement with special emphasis on small plaques (a hallmark of early atherosclerosis). The in vitro study consisted of nine phantoms of different volumes (small and medium-large) embedded at variable distances from the surface (superficial vs. >5 cm-depth) and comparison of 3DVUS data generated using a novel volumetric-linear array method with the real phantom volumes. The in vivo study was undertaken in a rabbit model of atherosclerosis in which 3DVUS and 2D/3D volume measurements were correlated against gold-standard histological measurements. In the in vitro setting, there was a strong correlation between 3DVUS measures and real phantom volume both for small (3.0-64.5 mm(3) size) and medium-large (91.1-965.5 mm(3) size) phantoms embedded superficially, with intraclass correlation coefficients (ICC) of 0.99 and 0.98, respectively; conversely, when phantoms were placed at >5 cm, the correlation was only moderate (ICC = 0.67). In the in vivo setting there was strong correlation between 3DVUS-measured plaque volumes and the histological gold-standard (ICC = 0.99 [4.02-92.5 mm(3) size]). Conversely, the correlation between 2D/3D values and the histological gold standard (sum of plaque areas) was weaker (ICC = 0.87 [49-520 mm(2) size]), with large dispersion of the differences between measurements in Bland-Altman plots (mean error, 79.2 mm(2)). 3DVUS using the volumetric-linear array method accurately measures plaque volumes, including those of small plaques. Measurements are more accurate for superficial arterial territories than for deep territories.es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshUltrasonography es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCohort Studies es_ES
dc.subject.meshHumans es_ES
dc.subject.meshImage Processing, Computer-Assistedes_ES
dc.subject.meshImaging, Three-Dimensionales_ES
dc.subject.meshLinear Models es_ES
dc.subject.meshPhantoms, Imaging es_ES
dc.subject.meshPlaque, Atherosclerotic es_ES
dc.subject.meshRabbits es_ES
dc.subject.meshReproducibility of Results es_ES
dc.subject.meshSoftware es_ES
dc.titleAccurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID27038420es_ES
dc.format.volume248es_ES
dc.format.page230-7es_ES
dc.identifier.doi10.1016/j.atherosclerosis.2016.03.002es_ES
dc.contributor.funderSociedad Española de Cardiología 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.atherosclerosis.2016.03.002es_ES
dc.identifier.journalAtherosclerosises_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzadaes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional