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dc.contributor.authorAdrover, Jose M 
dc.contributor.authorPellico, Juan
dc.contributor.authorFernández-Barahona, Irene
dc.contributor.authorMartin-Salamanca, Sandra 
dc.contributor.authorRuiz-Cabello, Jesus 
dc.contributor.authorHidalgo, Andrés 
dc.contributor.authorHerranz, Fernando
dc.date.accessioned2020-12-29T10:03:18Z
dc.date.available2020-12-29T10:03:18Z
dc.date.issued2020-11-26
dc.identifier.citationNanoscale. 2020; 12(45):22978-22987es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11568
dc.description.abstractRadioisotope-labelled nanoparticles permit novel applications in molecular imaging, while recent developments in imaging have enabled direct visualization of biological processes. While this holds true for pathological processes that are stable in time, such as cancer, imaging approaches are limited for phenomena that take place in the range of minutes, such as thrombotic events. Here, we take advantage of bioorthogonal chemistry to demonstrate the concept of nanoparticle-based fast pre-targeted imaging. Using a newly designed nanoparticle that targets platelets we show the applicability of this approach developing thrombo-tag, an in vivo produced nanoparticle that labels thrombi. We show that thrombo-tag allows specific labelling of platelets that accumulate in the injured pulmonary vasculature, or that aggregate in brains of mice suffering thrombotic processes. The fast kinetics and high specificity features of thrombo-tag may critically expand the application of molecular imaging to the most prevalent and debilitating diseases in the clinics.es_ES
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Science, grants number (SAF2016-79593-P, SAF2017-84494-C2-R and RED2018-102469-T), and from the Gobierno Vasco, Dpto. Industria, Innovación, Comercio y Turismo under the ELKARTEK Program (Grant No. KK-2019/bmG19). JR-C received funding from the BBVA Foundation (Ayudas a Equipos de investigación científica Biomedicina 2018). The study was also supported by Intramural grants from the Severo Ochoa program (IGP-SO), a grant from Fundació La Marató de TV3 (120/C/2015-20153032), grant SAF2015-65607-R from Ministerio de Ciencia e Innovacion (MICINN) with cofunding from Fondo Europeo de Desarrollo Regional, grant RTI2018-095497-B-I00 from MICINN, and HR17_00527 from Fundación La Caixa (to A. H.), and fellowship BES-2013-065550 from MICINN (to J. M. A.). The CNIC is supported by the MICINN and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MICINN award SEV-2015-0505). CIC biomaGUNE is supported by the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency – Grant No. MDM-2017-0720.es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleThrombo-tag, an in vivo formed nanotracer for the detection of thrombi in mice by fast pre-targeted molecular imaging.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID33053000es_ES
dc.format.volume12es_ES
dc.format.number45es_ES
dc.format.page22978-22987es_ES
dc.identifier.doi10.1039/d0nr04538aes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)
dc.contributor.funderGobierno Vasco
dc.contributor.funderFundación BBVA
dc.contributor.funderFundació La Marató
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.contributor.funderFundación La Caixa
dc.contributor.funderFundación ProCNIC
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1039/d0nr04538aes_ES
dc.identifier.journalNanoscalees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2016-79593-Pes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-84494-C2-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RED2018-102469-Tes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-65607-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-095497-B-I00es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BES-2013-065550es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MDM-2017-0720es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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