Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/11504
Título
Notch and interacting signalling pathways in cardiac development, disease, and regeneration.
Autor(es)
Fecha de publicación
2018-10
Cita
Nat Rev Cardiol. 2018; 15(11):685-704
Idioma
Inglés
Tipo de documento
journal article
Resumen
Cardiogenesis is a complex developmental process involving multiple overlapping stages of cell fate specification, proliferation, differentiation, and morphogenesis. Precise spatiotemporal coordination between the different cardiogenic processes is ensured by intercellular signalling crosstalk and tissue-tissue interactions. Notch is an intercellular signalling pathway crucial for cell fate decisions during multicellular organismal development and is aptly positioned to coordinate the complex signalling crosstalk required for progressive cell lineage restriction during cardiogenesis. In this Review, we describe the role of Notch signalling and the crosstalk with other signalling pathways during the differentiation and patterning of the different cardiac tissues and in cardiac valve and ventricular chamber development. We examine how perturbation of Notch signalling activity is linked to congenital heart diseases affecting the neonate and adult, and discuss studies that shed light on the role of Notch signalling in heart regeneration and repair after injury.
MESH
Receptor Cross-Talk | Regeneration | Signal Transduction | Animals | Animals, Genetically Modified | Cell Differentiation | Cell Lineage | Cell Proliferation | Fetal Heart | Heart Diseases | Heart Valves | Heart Ventricles | Humans | Models, Animal | Myocytes, Cardiac | Organogenesis | Receptors, Notch | Zebrafish
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- NotchIinteractingSignallingPat ...
- Tamaño:
- 2.471Mb
- Formato:
- Descripción:
- Artículo