Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/11183
Título
Myeloid cells in sensing of tissue damage.
Autor(es)
del Fresno, Carlos CNIC | Sancho, David CNIC
Fecha de publicación
2020-10-06
Cita
Curr Opin Immunol. 2020; 68:34-40
Idioma
Inglés
Tipo de documento
journal article
Resumen
Myeloid cells are components of the innate immune system that represent the first line of defense. Tissue damage, associated with pathological conditions such as infection, cancer or autoimmunity, leads to the exposure of the intracellular content to the extracellular environment. Myeloid cells detect ligands exposed or released by dead cells through specific receptors that signal for a diversity of responses. Inflammatory responses triggered by myeloid cells after sensing tissue injury can contribute to resolution of the damage. The signaling response following dead-cell sensing by myeloid cells can contribute either to an inflammatory or a regulatory response. We review herein some representative examples of how myeloid cells react to the recognition of cell death during specific tissue damage contexts. A deep understanding of the cellular and molecular mechanisms underlying these processes would allow to improve therapeutical interventions in pathologies associated with tissue damage.
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