dc.contributor.author | Sreenivasan, Krishnamoorthy | |
dc.contributor.author | Ianni, Alessandro | |
dc.contributor.author | Künne, Carsten | |
dc.contributor.author | Strilic, Boris | |
dc.contributor.author | Günther, Stefan | |
dc.contributor.author | Perdiguero, Eusebio | |
dc.contributor.author | Krüger, Marcus | |
dc.contributor.author | Spuler, Simone | |
dc.contributor.author | Offermanns, Stefan | |
dc.contributor.author | Gomez-del Arco, Pablo | |
dc.contributor.author | Gómez-Del Arco, Pablo | |
dc.contributor.author | Redondo, Juan Miguel | |
dc.contributor.author | Munoz-Canoves, Pura | |
dc.contributor.author | Kim, Johnny | |
dc.contributor.author | Braun, Thomas | |
dc.date.accessioned | 2020-06-10T07:41:13Z | |
dc.date.available | 2020-06-10T07:41:13Z | |
dc.date.issued | 2020-05-19 | |
dc.identifier.citation | Cell Rep. 2020; 31(7):107652 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/10318 | |
dc.description.abstract | Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore organ function is not fully understood. Here, we show that a substantial fraction of muscle stem cells (MuSCs) undergo necroptosis because of epigenetic rewiring during chronic skeletal muscle regeneration, which is required for efficient regeneration of dystrophic muscles. Inhibition of necroptosis strongly enhances suppression of MuSC expansion in a non-cell-autonomous manner. Prevention of necroptosis in MuSCs of healthy muscles is mediated by the chromatin remodeler CHD4, which directly represses the necroptotic effector Ripk3, while CHD4-dependent Ripk3 repression is dramatically attenuated in dystrophic muscles. Loss of Ripk3 repression by inactivation of Chd4 causes massive necroptosis of MuSCs, abolishing regeneration. Our study demonstrates how programmed cell death in MuSCs is tightly controlled to achieve optimal tissue regeneration. | es_ES |
dc.description.sponsorship | This work was supported by the DFG (Cardiopulmonary Institute [CPI], SFB TRR81 TP A02 and SFB 1213, TP A02 and B02); the LOEWE Center for Cell and Gene Therapy; the German Center for Cardiovascular Research; the European Research Area Network on Cardiovascular Diseases (grant CLARIFY); and Foundation Leducq. P.G.A. is supported by MICINN (SAF2016-77816-P). P.M.-C. acknowledges funding from grants RTI2018-096068-B-I00, MDM-2014-0370, SEV-2015-0505, ERC-2016-AdG-741966, La Caixa-HEALTH-HR17-00040, MDA, UPGRADE-H2020-825825, AFM, and DPP-E. T.B. is a member of the German Center for Cardiovascular Research (DZHK) and of the German Center for Lung Research (DZL) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 32433961 | es_ES |
dc.format.volume | 31 | es_ES |
dc.format.number | 7 | es_ES |
dc.format.page | 107652 | es_ES |
dc.identifier.doi | 10.1016/j.celrep.2020.107652 | es_ES |
dc.contributor.funder | German Centre for Cardiovascular Research | |
dc.contributor.funder | German Center for Lung Research (Alemania) | |
dc.contributor.funder | Fondation Leducq | |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2211-1247 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.celrep.2020.107652 | es_ES |
dc.identifier.journal | Cell reports | es_ES |
dc.repisalud.centro | ISCIII::Instituto de Investigación de Enfermedades Raras | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio de Regeneración Tisular | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Regulación Génica en Remodelado Vascular e Inflamación | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.repisalud.institucion | ISCIII | |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/741966 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2016-77816-P | es_ES |
dc.rights.accessRights | open access | es_ES |