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CCShared. Un caso de uso
Sesión 3.- Gestión y uso secundario de datos para investigación en el Espacio Europeo de Datos Sanitarios. Avanzando en conocimiento para una sociedad más saludable. Curso de verano de la Universidad Internacional Menéndez Pelayo, 2024.
Equidad en el acceso a la protección de la salud
Sesión 4.- Aspectos éticos en la investigación en biomedicina. Reflexiones desde el Comité de Bioética de España (CBE). Avanzando en conocimiento para una sociedad más saludable. Curso de verano de la Universidad Internacional Menéndez Pelayo, 2024.
Informe del Comité de Bioética de España sobre aspectos del uso secundario de los datos y el espacio europeo de protección de datos
Sesión 4.- Aspectos éticos en la investigación en biomedicina. Reflexiones desde el Comité de Bioética de España (CBE). Avanzando en conocimiento para una sociedad más saludable. Curso de verano de la Universidad Internacional Menéndez Pelayo, 2024.
3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release.
Traditional approaches to solid rectal therapies have halted progress, leading to a continual decline in the use of conventional suppositories. Additive manufacturing techniques have been recently explored as a suitable innovative tool for suppository fabrication. However, little advancement has be...
El ISCIII concede 90 millones para I+D+I en salud en 3 convocatorias: Unidades de Investigación Clínica, Medicina de Precisión y Enfermedades Raras
El Instituto de Salud Carlos III (ISCIII), como organismo dependiente del Ministerio de Ciencia, Innovación y Universidades, destina 90 millones para impulsar la investigación biomédica y sanitaria en España mediante tres nuevas convocatorias que financiarán iniciativas y proyectos de I+D+I en salu...
Circadian Effects on Vascular Immunopathologies.
Circadian rhythms exert a profound impact on most aspects of mammalian physiology, including the immune and cardiovascular systems. Leukocytes engage in time-of-day-dependent interactions with the vasculature, facilitating the emigration to and the immune surveillance of tissues. This review provid...
Improving paediatric asthma care in Zambia
Problem In 2008, the prevalence of paediatric asthma in Zambia was unknown and the national treatment guideline was outdated. Approach We created an international partnership between Zambian clinicians, the Zambian Government and a pharmaceutical company to address shortcomings in asthma treatment....
Empirically-derived food patterns and the risk of total mortality and cardiovascular events in the PREDIMED study
Background & aims: There is little evidence on post hoc-derived dietary patterns (DP) and all-cause mortality in Southern-European populations. Furthermore, the potential effect modification of a DP by a nutritional intervention has not been sufficiently assessed. We assessed the association betwee...
Benefits of the Mediterranean Diet: Insights From the PREDIMED Study
The PREDIMED (PREvenciOn con DIeta MEDiterranea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We randomized 7447 men and women at high CVD risk into three diets: MeDiet supplem...
Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?
Background and aim: We tested the hypothesis that an intervention with a Mediterranean diet (MeDiet) could mitigate the well-known harmful effects of abdominal obesity on cardiovascular health. Methods and results: We assessed the relationship between baseline waist-to-height ratio (WHtR) and major...
Intraoral paratrichosis after autograft
Background: Radial graft is one of the optimal treatments for reconstruction after tongue cancer, but it is not free of side effects. Hypertrichosis over the graft, causing an intraoral paratrichosis, might downgrade the quality of life and even require further interventions. Clinical case: The cas...
All-trans retinoic acid induces oxidative phosphorylation and mitochondria biogenesis in adipocytes
A positive effect of all-trans retinoic acid (ATRA) on white adipose tissue (WAT) oxidative and thermogenic capacity has been described and linked to an in vivo fat-lowering effect of ATRA in mice. However, little is known about the effects of ATRA on mitochondria in white fat. Our objective has be...
Body Mass Index and Doses at Organs at Risk in a Mediterranean Population Treated with Postoperative Vaginal Cuff Brachytherapy
Purpose: Association between body mass index (BMI) and doses in organs at risk during postoperative vaginal cuff brachytherapy (VCB) treatment has not been evaluated. The aim of this study was to analyse the impact of BMI on the dose delivered to bladder and rectum during high-dose-rate VCB using c...
A simplified equation for total energy expenditure in mechanically ventilated critically ill patients
Introduction: tight calorie control concept arose to avoid over- and under-feeding of patients. Objective: to describe and validate a simplified predictive equation of total energy expenditure (TEE) in mechanically ventilated critically ill patients. Methods: this was a secondary analysis of measur...
Compliance of nutritional recommendations of Spanish pregnant women according to sociodemographic and lifestyle characteristics: a cohort study
Objective: To assess nutrient intakes and compliance with nutritional recommendations in pregnant women according to selected sociodemographic characteristics and lifestyles. Methods: Cross-sectional study based on data from Spanish PIMA cohort which recruited 2,585 pregnant women between 2003 and ...
The Mediterranean Diet and micronutrient levels in depressive patients
Introduction: An inverse association between depression and some serum micronutrient levels (selenium, zinc, iron, magnesium, vitamin B and folic acid) has been reported. In addition, other studies reported that this micronutrient supplementation may improve depressed mood. The Mediterranean diet c...
Synergistic Effects of a Mixture of Glycosaminoglycans to Inhibit Adipogenesis and Enhance Chondrocyte Features in Multipotent Cells
Background/Aims: Multipotent mesenchymal stem cells affect homeostasis of adipose and joint tissues. Factors influencing their differentiation fate are of interest for both obesity and joint problems. We studied the impact of a mixture of glycosaminoglycans (GAGs) (hyaluronic acid: dermatan sulfate...
Leptin Rapidly Induces the Expression of Metabolic and Myokine Genes in C2C12 Muscle Cells to Regulate Nutrient Partition and Oxidation
Background: Skeletal muscle can experience pronounced metabolic adaptations in response to extrinsic stimuli, and expresses leptin receptor (OB-Rb). We aimed to further the understanding of leptin effects on muscle cells, by studying the expression of key energy metabolism genes in C2C12 myotubes. ...
Quality of life and its determinants in Spanish university students of health sciences factors
Introduction: The quality of life of university students acquires special importance because it provides information about their life conditions and especially how they perceive it. Objetive: Evaluate the quality of life of students who are enrolled in health science studies and its relation with t...