Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 107.473 exceso de defunciones por todas las causas y 7.377 defunciones atribuibles a temperatura.

Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 104.443 exceso de defunciones por todas las causas y 7.400 defunciones atribuibles a temperatura.

Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 103.980 exceso de defunciones por todas las causas y 7.281 defunciones atribuibles a temperatura.

Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 102.311 exceso de defunciones por todas las causas y 6.638 defunciones atribuibles a temperatura.

Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 99.915 exceso de defunciones por todas las causas y 6.567 defunciones atribuibles a temperaturas.

Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 101.645 exceso de defunciones por todas las causas y 6.569 defunciones atribuibles a temperatura.

The p63 protein has pleiotropic functions and, in the liver, participates in the progression of nonalcoholic fatty liver disease (NAFLD). However, its functions in hepatic stellate cells (HSCs) have not yet been explored. TAp63 is induced in HSCs from animal models and patients with liver fibrosis ...

BACKGROUND The presence of coronary plaques with high-risk characteristics is strongly associated with adverse cardiac events beyond the identification of coronary stenosis. Testing by coronary computed tomography angiography (CCTA) enables the identification of high-risk plaques (HRP). Referral f...

The metabolic functions of the liver are spatially organized in a phenomenon called zonation, linked to the differential exposure of portal and central hepatocytes to nutrient-rich blood. The mTORC1 signaling pathway controls cellular metabolism in response to nutrients and insulin fluctuations. He...

Intravital microscopy has revolutionized live-cell imaging by allowing the study of spatial-temporal cell dynamics in living animals. However, the complexity of the data generated by this technology has limited the development of effective computational tools to identify and quantify cell processes...

Coenzyme Q (Q) is a key lipid electron transporter, but several aspects of its biosynthesis and redox homeostasis remain undefined. Various flavoproteins reduce ubiquinone (oxidized form of Q) to ubiquinol (QH2); however, in eukaryotes, only oxidative phosphorylation (OXPHOS) complex III (CIII) oxi...

BACKGROUND Transthyretin cardiac amyloidosis (ATTR amyloidosis) is a frequent etiology of heart failure. Inflammation and mineral metabolism are associated with myocardial dysfunction and clinical performance. Cardiac global longitudinal strain (GLS) allows function assessment and is associated wi...

Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion (I/R) injury remains incomplete. We here inves...

BACKGROUND AND PURPOSE This study analyses whether first-line antihypertensive drugs ameliorate the dysbiosis state in hypertension, and to test if this modification contributes to their blood pressure (BP) lowering properties in a genetic model of neurogenic hypertension. EXPERIMENTAL APPROACH ...

Background: The microbiological procedures for cystic fibrosis (CF) samples of 17 participating Spanish centers were examined to verify their compliance with current international and national guidelines and to implement the best standards of care for microbiology practices. A 47-item questionnaire...

Androgen deprivation treatment is the current standard first-line treatment for metastatic prostate cancer. For several years, docetaxel was the only treatment with a proven survival benefit for castration-resistant prostate cancer (CRPC). Since docetaxel became standard of care for men with sympto...

Ovarian cancer is the leading cause of death due to gynecological cancer and the 5th cause of death for cancer in women in Europe. Optimal management of patients with ovarian cancer needs the participation of a well-trained multidisciplinary team. In the last few years, we have observed a significa...