We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common ...

The main aim of this study is to describe the relationship between serum levels of atazanavir, renal toxicity, and lithiasis. This is a prospective observational study of patients being treated with atazanavir (ATV) at Son Espases Teaching Hospital, Palma de Mallorca, between 2011 and 2013. The stu...

Introduction: Despite the availability of new antibiotics such as daptomycin, methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia continues to be associated with high clinical failure rates. Combination therapy has been proposed as an alternative to improve outcomes but there is a lack o...

Background: Some patients share characteristics of both COPD and asthma. As yet, there is no gold standard to identify patients with the so-called asthma-COPD overlap syndrome (ACOS). Objective: To describe the differences between ACOS patients and the remaining COPD patients, and to compare the cl...

Nephrolithiasis is a complex disease that results from a combination of factors related to both urine composition and kidney morphoanatomy. Development of calcium oxalate monohydrate papillary calculi is linked to initial subepithelial calcification of renal papilla. Progressive tissue calcificatio...

Improving coverage, robustness, and sensitivity is crucial for routine phosphoproteomics analysis by single-shot liquid chromatography-tandem mass spectrometry (LC-MS/MS) from minimal peptide inputs. Here, we systematically optimized key experimental parameters for automated on-bead phosphoproteomi...

Selective Plane Illumination Microscopy (SPIM) has become an emerging technology since its first application for 3D in-vivo imaging of the development of a living organism. An extensive number of works have been published, improving both the speed of acquisition and the resolution of the systems. F...

Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 126.086 exceso de defunciones por todas las causas y 11.290 defunciones atribuibles a temperatura.

Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 126.254 exceso de defunciones por todas las causas y 11.290 defunciones atribuibles a temperatura.

Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 126.032 exceso de defunciones por todas las causas y 11.287 defunciones atribuibles a temperatura.

Desde el 01 de enero de 2020 MoMo ha identificado a nivel nacional 126.159 exceso de defunciones por todas las causas y 11.286 defunciones atribuibles a temperatura.

BACKGROUND Cancer-therapy-related cardiac dysfunction (CTRCD) is a growing concern for public health, with a growing incidence due to improved survival rates of patients with hematological malignancies due to diagnostic and therapeutic advances. The identification of patients at risk for CTRCD is ...

El Instituto de Salud Carlos III (ISCIII), como organismo dependiente del Ministerio de Ciencia, Innovación y Universidades, dispone de dos herramientas, desarrolladas y gestionadas desde el Centro Nacional de Epidemiología (CNE)​, que permiten llevar a cabo estimaciones sobre posibles excesos de m...

El Instituto de Salud Carlos III (ISCIII) ha coorganizado en Santander, junto con la Universidad Internacional Menéndez Pelayo (UIMP), un curso de verano sobre avances en investigación biomédica y sanitaria. A lo largo de los dos días de duración del curso, se han tratado cuestiones como la Investi...

Curcumin is a natural molecule widely tested in preclinical and clinical studies due to its antioxidant and anti-inflammatory activity. Nevertheless, its high hydrophobicity and low bioavailability limit in vivo applications. To overcome curcumin´s drawbacks, small extracellular vesicles (sEVs) hav...

Lung diseases develop when telomeres shorten beyond a critical point. We constructed a mouse model in which the catalytic subunit of telomerase (mTert), or its catalytically inactive form (mTertCI), is expressed from the p21Cdkn1a locus. Expression of either TERT or TERTCI reduces global p21 levels...

BACKGROUND Less than 40% of patients with dilated cardiomyopathy (DCM) have a pathogenic/likely pathogenic genetic variant identified. TBX20 has been linked to congenital heart defects; although an association with left ventricular noncompaction (LVNC) and DCM has been proposed, it is still consid...

Targeting epigenetic mechanisms has emerged as a potential therapeutic approach for the treatment of kidney diseases. Specifically, inhibiting the bromodomain and extra-terminal (BET) domain proteins using the small molecule inhibitor JQ1 has shown promise in preclinical models of acute kidney inju...